CC-885

Catalog No.S8300 Batch:S830002

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Technical Data

Formula

C22H21ClN4O4
Molecular Weight 440.88 CAS No. 1010100-07-8
Solubility (25°C)* In vitro DMSO 88 mg/mL (199.6 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description

CC-885 is a novel cereblon (CRBN) modulator. CC-885 selectively promotes CRBN- and p97-dependent PLK1 ubiquitination and degradation.
Targets
CRBN [1]
In vitro

CC-885 selectively promotes CRBN- and p97-dependent PLK1 ubiquitination and degradation in non-small-cell lung cancer (NSCLC) cells.<sup><a class="sref" href="#s_ref">[1]</a></sup>
In vivo

CC-885 can promote PLK1 ubiquitination and degradation and synergistically inhibit NSCLC with volasertib in NSCLC model BALB/cA nude mice.<sup><a class="sref" href="#s_ref">[1]</a></sup>

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    A549, NCI-H1299

  • Concentrations

    50 nM, 1 mM

  • Incubation Time

    24 h, 48 h

  • Method

    A549 and NCI-H1299 are treated with 1 mM CC-885 for 24 h and subjected to immunoblot analysis.
Animal Study:

[1]
  • Animal Models

    NSCLC model BALB/cA nude mice inoculated with A549 cells

  • Dosages

    20 mg/kg

  • Administration

    i.p.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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