Carbenicillin disodium

Catalog No.S3179 Batch:S317901

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Technical Data

Formula

C17H16N2Na2O6S

Molecular Weight 422.36 CAS No. 4800-94-6
Solubility (25°C)* In vitro Water 84 mg/mL (198.88 mM)
DMSO 5 mg/mL (11.83 mM)
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Carbenicillin (BRL-2064,α-carboxybenzylpenicillin) is a semi-synthetic penicillin antibiotic which interferes with cell wall synthesis of gram-negative bacteria while displaying low toxicity.
In vitro

Carbenicillin (125 mg/L) completely suppresses the proliferation of Agrobacterium. Carbenicillin (250 mg/L-500 mg/L) enhances Callus fresh weight increase. Carbenicillin (125 mg/L) results in higher percentages of somatic embryos and larger numbers of somatic embryos from the individual callus. [1] Carbenicillin (1g/L) influences shoot formation negatively as the shooting frequency for leaf disc explants is reduced to 56% and for cotyledons to 51% after 2 months of culture of Nicotiana tabacum Petit Havana. [2] Carbenicillin prevents the development of mature somatic embryos, reduces early stage embryos by >90% and tissue growth by 50% of Sitka spruce. [3] The leukocytes of the patients does not release histamine on in vitro provocation with Carbenicillin (0.1 g/mL). [4]

In vivo

Carbenicillin (0.1 g/mL) does not show any allergic drug reactions in cystic fibrosis patients, as evident by no significant levels of antibodies of IgE, IgG or IgM classes. [4] Carbenicillin (50 μg/mL) results in phytotoxicity in chrysanthemum and TOB, with an increase in the concentration, and with a parallel shift in the morphogenic capacity (SRC) of threshold survival levels (TSLs). Carbenicillin results in 100% acclimatization with no different morphological flowering characteristics following subculture in vitro three times in Chrysanthemum plantlets. [5]

Protocol (from reference)

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.