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Technical Data
| Formula | C17H20N6O4S |
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| Molecular Weight | 404.44 | CAS No. | 1619994-69-2 | |
| Solubility (25°C)* | In vitro | DMSO | 81 mg/mL (200.27 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Bromosporine is a broad spectrum inhibitor for bromodomains with IC50 of 0.41 μM, 0.29 μM, 0.122 μM and 0.017 μM for BRD2, BRD4, BRD9 and CECR2, respectively. | ||||||||
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| Targets |
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| In vitro | In cell-based assays, Bromosporine (1 µM) accelerates FRAP recovery of BRD4 and CREBBP, while shows no activities against TIF1α, BAZ2A, and SMARCA2 even at 10 µM. Bromosporine shows moderate cytotoxicity in HeLa cells at 18 µM. Bromosporine, as a chemical probe for bromodomain functional assays, will be very useful in elucidating further biological roles of reader domains. [2] |
Protocol (from reference)
Selleck's Bromosporine has been cited by 6 publications
| Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain [ J Med Chem, 2022, 65(5):4182-4200] | PubMed: 35191694 |
| BPTF promotes the progression of distinct subtypes of breast cancer and is a therapeutic target [ Front Oncol, 2022, 12:1011173] | PubMed: 36530982 |
| Epigenetic Reprogramming with Antisense Oligonucleotides Enhances the Effectiveness of Androgen Receptor Inhibition in Castration-Resistant Prostate Cancer [ Cancer Res, 2018, 78(20):5731-5740] | PubMed: 30135193 |
| Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes [ Elife, 2018, 7e38519] | PubMed: 30412052 |
| Activity of bromodomain protein inhibitors/binders against asexual-stage Plasmodium falciparum parasites [Chua MJ, et al. Int J Parasitol Drugs Drug Resist, 2018, 8(2):189-193] | PubMed: 29631126 |
| The bromodomain and extraterminal domain inhibitor bromosporine synergistically reactivates latent HIV-1 in latently infected cells. [ Oncotarget, 2017, 8(55):94104-94116] | PubMed: 29212213 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.