Bay K 8644

Catalog No.S7924 Batch:S792402

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Technical Data

Formula

C16H15F3N2O4
Molecular Weight 356.30 CAS No. 71145-03-4
Solubility (25°C)* In vitro DMSO 71 mg/mL (199.27 mM)
Ethanol 71 mg/mL (199.27 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Bay K 8644 is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM.
Targets
L-type calcium channel [1]
(in the isolated field-stimulated vas deferens of the mouse)
17.3nM(EC50)
In vitro

Bay K 8644 increases resting tension in segments of mesenteric arteries isolated from young and old rats as an agonist of L-type Ca2+ channel[2]
In vivo

Bay K 8644 induces small contractions in aortae from Wistar-Kyoto(WKY) rats of 5-week-, 3-month-, 1-year-, 1.5-year-old, which are unaltered with age.[3]

Protocol (from reference)

Cell Assay:

[4]
  • Cell lines

    5TGM1 cells

  • Concentrations

    10 nM

  • Incubation Time

    30 minutes

  • Method

    Cells were treated with indicated concentration of drug for 30 minutes.
Animal Study:

[5]
  • Animal Models

    Male Sprague-Dawley rats

  • Dosages

    1, 10, 50 and 100 µg/kg

  • Administration

    Jugular catheters

Customer Product Validation

Data from [Data independently produced by , , J Cell Physiol, 2018, doi:10.1002/jcp.27791]

Selleck's Bay K 8644 has been cited by 5 publications

Apoptotic Extracellular Vesicles Ameliorate Multiple Myeloma by Restoring Fas-Mediated Apoptosis [ ACS Nano, 2021, 10.1021/acsnano.1c03517] PubMed: 34506129
Low doses of BPF-induced hypertrophy in cardiomyocytes derived from human embryonic stem cells via disrupting the mitochondrial fission upon the interaction between ERβ and calcineurin A-DRP1 signaling pathway [ Cell Biol Toxicol, 2021, 10.1007/s10565-021-09615-y] PubMed: 34023961
Calenduloside E suppresses calcium overload by promoting the interaction between L-type calcium channels and Bcl2-associated athanogene 3 to alleviate [ Journal of Advanced Research, 2020, 10.1016/j.jare.2020.10.005] PubMed: None
Sulfur Dioxide Activates Cl-/HCO3- Exchanger via Sulphenylating AE2 to Reduce Intracellular pH in Vascular Smooth Muscle Cells [ Front Pharmacol, 2019, 10:313] PubMed: 30971931
Ranolazine prevents pressure overload-induced cardiac hypertrophy and heart failure by restoring aberrant Na+ and Ca2+ handling [Nie J, et al. J Cell Physiol, 2018, 10.1002/jcp.27791 ] PubMed: 30488495

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.