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Technical Data
| Formula | CH6N4.HCl |
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| Molecular Weight | 110.55 | CAS No. | 1937-19-5 | |
| Solubility (25°C)* | In vitro | DMSO | 22 mg/mL (199.0 mM) | |
| Water | 22 mg/mL (199.0 mM) | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Aminoguanidine (Pimagedine, Guanyl hydrazine, Hydrazinecarboximidamide, Imino semicarbazide, Monoaminoguanidine) is a diamine oxidase and nitric oxide synthase inhibitor. It acts to reduce levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone. | |||
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| Targets |
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| In vivo | Aminoguanidine ameliorates neonatal hypoxic-ischemic brain damage and that temporal profiles of NO correlated with the neuroprotective effect of aminoguanidine. Neuroprotection by AG is attributable to suppression of NO produced by iNOS after the end of the hypoxic period, during the reoxygenation phase. The half-life of AG is estimated to be between 6 and 8 h in vivo and approximately 4.4 h in human with normal renal function.AG is also an inhibitor of the formation of advanced glycation end products. Systematically administered advanced glycation end product–modified BSA increases cerebral infarct size in an adult rat, which is attenuated by AG[2]. |
Protocol (from reference)
| Animal Study: |
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References
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Selleck's Aminoguanidine hydrochloride has been cited by 7 publications
| Effect of calcium-sensing receptor on the migration and proliferation of porcine intestinal epithelial cells [ Anim Biotechnol, 2021, 1-10] | PubMed: 34459707 |
| Effects of spermine on the proliferation and migration of porcine intestinal epithelial cells [ Anim Biotechnol, 2021, 1-8] | PubMed: 34369303 |
| CLIC4 Regulates Radioresistance of Nasopharyngeal Carcinoma by iNOS After γ-rays but Not Carbon Ions Irradiation [ Am J Cancer Res, 2020, 10(5):1400-1415] | PubMed: 32509387 |
| Angiogenesis impairment by the NADPH oxidase-triggered oxidative stress at the bone-implant interface: Critical mechanisms and therapeutic targets for implant failure under hyperglycemic conditions in diabetes [Hu XF, et al. Acta Biomater, 2018, 73:470-487] | PubMed: 29649637 |
| Rapamycin Nano-Micelle Ophthalmic Solution Reduces Corneal Allograft Rejection by Potentiating Myeloid-Derived Suppressor Cells' Function [Wei C, et al. Front Immunol, 2018, 9:2283] | PubMed: 30349533 |
| Lactic acid of PLGA coating promotes angiogenesis on the interface between porous titanium and diabetic bone [ J Mater Chem B, 2018, 6(15):2274-2288] | PubMed: 32254567 |
| Lactic acid of PLGA coating promotes angiogenesis on the interface between porous titanium and diabetic bone [Xiao-Fan Hu, et al. J Mater Chen B, 2018, 10.1039/C7TB03247A] |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.