Amenamevir

Catalog No.S5552 Batch:S555202

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Technical Data

Formula

C24H26N4O5S
Molecular Weight 482.55 CAS No. 841301-32-4
Solubility (25°C)* In vitro DMSO 96 mg/mL (198.94 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Amenamevir (ASP2151) is a potent helicase-primase inhibitor and a novel class of antiviral agent.
Targets
helicase-primase [1]
In vitro ASP2151 inhibited the in vitro replication of HSV-1. The mean EC50s of ASP2151 against HSV-1 and HSV-2 were 14 (range, 7.7 to 20) and 30 ng/ml (range, 15 to 58), respectively[2].
In vivo In the cutaneously HSV-1-infected mouse model, ASP2151 dose dependently suppressed intradermal HSV-1 growth, with the effect reaching a plateau at a dose of 30 mg/kg of body weight/day[2].

Protocol (from reference)

Animal Study:

[2]
  • Animal Models

    HSV-1-infected mice

  • Dosages

    1, 3, 10, 30, or 100 mg/kg/day

  • Administration

    oral

Selleck's Amenamevir has been cited by 1 publication

Repurposing of FDA approved drugs against Salmonella enteric serovar Typhi by targeting dihydrofolate reductase: an in silico study [ J Biomol Struct Dyn, 2020, 1-14] PubMed: 33251976

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.