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Technical Data
| Formula | C23H13Cl2N3O2 |
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| Molecular Weight | 434.27 | CAS No. | 304896-28-4 | |
| Solubility (25°C)* | In vitro | DMSO | 4 mg/mL (9.21 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels. | ||
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| In vitro | In SIRT2-myc-expressing HeLa cells, AGK2 effectively inhibits the activity of SIRT2, and increases acetylated tubulin. AGK2 protects dopaminergic neurons from α-Syn–induced toxicity in primary midbrain cultures. [1] AGK2 induces both necrosis and caspase-3-dependent apoptosis in C6 glioma cells. [2] SIRT2 also decreases merlin-mutant viability of mouse schwann cells (MSCs) without substantially reducing wild-type MSC viability. [3] | ||
| In vivo | In drosophila model of parkinson's disease, AGK2 rescues α-Syn–mediated toxicity and modify aggregation. [1] |
Protocol (from reference)
| Animal Study: |
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References
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Customer Product Validation
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Data from [Data independently produced by , , Cell Physiol Biochem, 2018, 46(2):451-460]
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Data from [Data independently produced by , , Mol Cancer Res, 2018, doi:10.1158/1541-7786.MCR-18-0637]
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Data from [Data independently produced by , , J Biol Chem, 2014, 289(9): 6054-66 ]
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Data from [Data independently produced by , , Cancer Biol Ther, 2018, 19(9):835-846]
Selleck's AGK2 has been cited by 31 publications
| Mitochondrial aldehyde dehydrogenase-2 coordinates the hydrogen sulfide - AMPK axis to attenuate high glucose-induced pancreatic β-cell dysfunction by glutathione antioxidant system [ Redox Biol, 2024, 69:102994] | PubMed: 38128451 |
| SIRT2 inhibition protects against cardiac hypertrophy and ischemic injury [ Elife, 2023, 12e85571] | PubMed: 37728319 |
| SIRT2 inhibition protects against cardiac hypertrophy and ischemic injury [ Elife, 2023, 12e85571] | PubMed: 37728319 |
| SIRT2 Inhibition Rescues Neurodegenerative Pathology but Increases Systemic Inflammation in a Transgenic Mouse Model of Alzheimer's Disease [ J Neuroimmune Pharmacol, 2023, 18(3):529-550] | PubMed: 37698780 |
| Continuous Fluorescent Sirtuin Activity Assay Based on Fatty Acylated Lysines [ Int J Mol Sci, 2023, 24(8)7416] | PubMed: 37108579 |
| VRK1 Kinase Activity Modulating Histone H4K16 Acetylation Inhibited by SIRT2 and VRK-IN-1 [ Int J Mol Sci, 2023, 24(5)4912] | PubMed: 36902348 |
| High-Content and High-Throughput Clonogenic Survival Assay Using Fluorescence Barcoding [ Cancers -Basel), 2023, 15(19)4772] | PubMed: 37835466 |
| AGK2 pre-treatment protects against thioacetamide-induced acute liver failure via regulating the MFN2-PERK axis and ferroptosis signaling pathway [ Hepatobiliary Pancreat Dis Int, 2023, S1499-3872(23)00037-1] | PubMed: 36966125 |
| Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells [ Dev Cell, 2022, 57(2):260-276.e9] | PubMed: 35077680 |
| Arylamine N-Acetyltransferase 1 Activity is Regulated by the Protein Acetylation Status [ Front Pharmacol, 2022, 13:797469] | PubMed: 35153780 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.