|
Toll Free: (877) 796-6397 -- USA and Canada only -- |
Fax: +1-832-582-8590 Orders: +1-832-582-8158 |
Tech Support: +1-832-582-8158 Ext:3 Please provide your Order Number in the email. |
Technical Data
| Formula | C8H12N5O4P |
|||
| Molecular Weight | 273.19 | CAS No. | 106941-25-7 | |
| Solubility (25°C)* | In vitro | 5%TFA | 6.04 mg/mL (22.1 mM) | |
| Water | 0.1 mg/mL (0.36 mM) | |||
| DMSO | Insoluble | |||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
||||
Preparing Stock Solutions
Biological Activity
| Description | Adefovir is an orally administered nucleotide analog reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection. | |
|---|---|---|
| Targets |
|
|
| In vitro | In vitro, adefovir is a potent inhibitor of viral replication in human hepatoma cell lines stably transfected with HBV and in primary duck hepatocytes infected with duck HBV (DHBV). Adefovir does not prevent initiation of infection in primary duck hepatocyte cultures. Adefovir is also reported to exhibit immunomodulatory effects, including stimulation of natural killer cell activity and interferon alpha production[1]. | |
| In vivo | Adefovir has a poor oral bioavailability and it is usually used via intraperitoneal injection[1]. |
Protocol (from reference)
Selleck's Adefovir has been cited by 1 publication
| Nucleos(t)ide analogs for hepatitis B virus infection differentially regulate the growth factor signaling in hepatocytes [ Hepatol Commun, 2024, 8(1)e0351] | PubMed: 38180972 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.