α-L-Rhamnose monohydrate

Catalog No.S3887 Batch:S388701

Technical Data

Formula	C₆H₁₂O₅.H₂O
Molecular Weight	182.17	CAS No.	6155-35-7
Solubility (25°C)*	In vitro	DMSO	36 mg/mL (197.61 mM)


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description	α-L-Rhamnose monohydrate (6-deoxy-L-mannose monohydrate, α-L-Rhamnopyranose monohydrate) is used as a starting material for the production of furanones. It is an important material involved in the reaction of flavors developed during the preparation of various foods like bread, grilled meats, etc.
In vitro	L-rhamnose in concentration up to 20 (32 resp.) mmol/l can not be considered as cytotoxic or cytostatic for the used in vitro tumor models^[1].
In vivo	L-rhamnose exerts a significant suppressive effect on tumour growth. Its optimal dose is estimated to be 3.64 g/kg/day^[2].

Protocol (from reference)

Cell Assay:^{^[1]}	Cell lines HL-60 cells Concentrations 0.125 mmol/l to 32 mmol/l Incubation Time 48 h Method At the beginning of the experiment, HL-60 cells are diluted to a concentration of 2x10⁵/ml. Exponential growth of control cells is apparent during the observation interval. HL-60 cells are exposed to L-rhamnose or 2-deoxyglucose in final concentration from 0.125 mmol/l to 32 or 16 mmol/l, resp., in full cultivating medium.
Animal Study:^{^[2]}	Animal Models NMRI female mice Dosages 1, 3, or 5 g/kg/day Administration i.p.

Cell Assay:^{^[1]}

Cell lines
HL-60 cells
Concentrations
0.125 mmol/l to 32 mmol/l
Incubation Time
48 h
Method
At the beginning of the experiment, HL-60 cells are diluted to a concentration of 2x10⁵/ml. Exponential growth of control cells is apparent during the observation interval. HL-60 cells are exposed to L-rhamnose or 2-deoxyglucose in final concentration from 0.125 mmol/l to 32 or 16 mmol/l, resp., in full cultivating medium.

Animal Study:^{^[2]}

Animal Models
NMRI female mice
Dosages
1, 3, or 5 g/kg/day
Administration
i.p.

References

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.