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Technical Data
| Formula | C20H27NO3 |
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| Molecular Weight | 329.43 | CAS No. | 13647-35-3 | |
| Solubility (25°C)* | In vitro | DMSO | 65 mg/mL (197.31 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Trilostane (WIN 24540) is an inhibitor of 3β-hydroxysteroid dehydrogenase used in the treatment of Cushing’s syndrome. | |
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| In vitro | Both Trilostane and 4-Hydroxy tamoxifen (OHT) affects transcription of genes involved in cell cycle regulation, cell adhesion and matrix formation, however, only 12.5% of Trilostane down-regulated genes and 9.2% of up-regulated genes are similarly regulated by OHT in MCF-7 cells.?sup>[1] | |
| In vivo | Trilostane treatment results in a significant decline in basal plasma cortisol concentrations in dogs. Trilostane treatment results in an insignificant decrease in plasma aldosterone concentration (PAC), but the median plasma renin activity (PRA) at the time the trilostane dosage is considered optimal (265 fmol/L/s, range 70-3280 fmol/L/s; n=18) is significantly higher than prior to treatment (115 fmol/L/s, range 15-1330 fmol/L/s). Trilostane affects both the hypothalamic-pituitary-adrenocortical and the renin-aldosterone axes. [2] Trilostane effectively blocks the increase in systolic blood pressure and reverses the hypertension produced by drinking 0.9% saline in the Dahlsalt-sensitive rat. Trilostane is equally effective in female and male rats. [3] Trilostane reduces clinical signs and improves endocrine test results in all cats, but insulin requirements does not change and all continued to have some signs of hypercortisolemia. [4] Trilostane results in a reduction in serum cortisol and aldosteroneconcentrations in dogs with PDH, although the decrease for serum aldosterone concentration is smaller than that for serum cortisol concentration. [1] |
Protocol (from reference)
References
Customer Product Validation
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Data from [Data independently produced by Cell Mol Life Sci, 2014, 71(9), 1723-40]
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Data from [Data independently produced by J Mol Endocrinol, 2014, 53(2), 175-90]
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Data from [Biol Reprod, 2012, 87, 35 ]
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Data from [Data independently produced by , , Biochim Biophys Acta Mol Cell Biol Lipids, 2018, 1863(6):625-638]
Selleck's Trilostane has been cited by 9 publications
| Trilostane, a 3β-hydroxysteroid dehydrogenase inhibitor, suppresses growth of hepatocellular carcinoma and enhances anti-cancer effects of sorafenib [ Invest New Drugs, 2021, 10.1007/s10637-021-01132-3] | PubMed: 34031786 |
| Dehydroepiandrosterone Prevents H2O2-Induced BRL-3A Cell Oxidative Damage through Activation of PI3K/Akt Pathways rather than MAPK Pathways. [ Oxid Med Cell Longev, 2019, 10.1155/2019/2985956] | PubMed: 31182991 |
| Dehydroepiandrosterone reduces accumulation of lipid droplets in primary chicken hepatocytes by biotransformation mediated via the cAMP/PKA-ERK1/2 signaling pathway [Li L Biochim Biophys Acta Mol Cell Biol Lipids, 2018, 1863(6):625-638] | PubMed: 29571766 |
| The Adrenal Lipid Droplet is a New Site for Steroid Hormone Metabolism [Yu J Proteomics, 2018, 18(23):e1800136] | PubMed: 30358111 |
| Gonadotropin-Activated Androgen-Dependent and Independent Pathways Regulate Aquaporin Expression during Teleost (Sparus aurata) Spermatogenesis [Boj M PLoS One, 2015, 10(11):e0142512] | PubMed: 26575371 |
| Gonadotropin-Activated Androgen-Dependent and Independent Pathways Regulate Aquaporin Expression during Teleost (Sparus aurata) Spermatogenesis. [Boj M, et al. PLoS One, 2015, 10(11):e0142512] | PubMed: 26575371 |
| Long-term incubation with mifepristone (MLTI) increases the spine density in developing Purkinje cells: new insights into progesterone receptor mechanisms. [Wessel L, et al. Cell Mol Life Sci, 2014, 71(9):1723-40] | PubMed: 23982753 |
| Fsh and Lh direct conserved and specific pathways during flatfish semicystic spermatogenesis [Chauvigne F et al. J Mol Endocrinol, 2014, 53(2):175-90] | PubMed: 25024405 |
| Follicle-Stimulating Hormone and Luteinizing Hormone Mediate the Androgenic Pathway in Leydig Cells of an Evolutionary Advanced Teleost. [Chauvigné F, et al. Biol Reprod, 2012, 87(2):35] | PubMed: 22649073 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.