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Technical Data
| Formula | C38H42N2O6 |
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| Molecular Weight | 622.75 | CAS No. | 518-34-3 | |
| Solubility (25°C)* | In vitro | DMSO | 7 mg/mL (11.24 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Tetrandrine, a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a calcium channel blocker. | |
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| In vitro | Tetrandrine inhibits voltage-gated Ca2+ currents with an IC50 of 10.1 mM in isolated nerve terminals of the rat neurohypophysis. Tetrandrine is a high-affinity blocker of the type II, maxi-Ca(2+)-activated K+ channel of the rat neurohypophysial terminals with an IC50 of 0.21 mM. [1] Another study shows that Tetrandrine also inhibits Ca(2+)-activated Cl- currents (I(Cl,Ca)) with an IC50 of 5.2 mM. [2] Tetrandrine inhibits the proliferation of human leukemic HL-60 cells via induction of apoptosis. [3] | |
| In vivo | LD50: Mice 158.9mg/kg (i.v.) [4], 365mg/kg (i.p.) [5]; Rats 646mg/kg (i.g.) [6] |
Protocol (from reference)
References
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Customer Product Validation
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Data from [Data independently produced by , , FASEB J, 2018, 32(6):3398-3410]
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Data from [Data independently produced by , , Biochemical and Biophysical Research Communications, 2016, 476(4):481-486.]
Selleck's Tetrandrine has been cited by 14 publications
| Calpain-2 mediates SARS-CoV-2 entry via regulating ACE2 levels [ mBio, 2024, e0228723.] | PubMed: 38349185 |
| Tetrandrine (TET) inhibits African swine fever virus entry into cells by blocking the PI3K/Akt pathway [ Virus Res, 2024, 339:199258] | PubMed: 37923171 |
| Calcium Signaling in MR1-Dependent Antigen Presentation of Mycobacterium tuberculosis [ Res Sq, 2023, rs.3.rs-3154465] | PubMed: 37693580 |
| Calcium Signaling in MR1-Dependent Antigen Presentation of Mycobacterium tuberculosis [ Res Sq, 2023, rs.3.rs-3154465] | PubMed: 37693580 |
| Tetrandrine inhibits RANKL-induced osteoclastogenesis by promoting the degradation of TRAIL [ Mol Med, 2022, 28(1):141] | PubMed: 36435772 |
| Growth-Suppressive and Apoptosis-Inducing Effects of Tetrandrine in SW872 Human Malignant Liposarcoma Cells via Activation of Caspase-9, Down-Regulation of XIAP and STAT-3, and ER Stress [ Biomolecules, 2022, 12(6)843] | PubMed: 35740967 |
| Tetrandrine attenuates intestinal epithelial barrier defects caused by colitis through promoting the expression of Occludin via the AhR-miR-429 pathway [ FASEB J, 2021, 35(5):e21502] | PubMed: 33811696 |
| Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV. [ Nat Commun, 2020, 27;11(1):1620] | PubMed: 32221306 |
| Tetrandrine attenuates hyperoxia-induced lung injury in newborn rats via NF-κB p65 and ERK1/2 pathway inhibition [ Ann Transl Med, 2020, 8(16):1018] | PubMed: 32953818 |
| Tetrandrine enhances the ubiquitination and degradation of Syk through an AhR-c-src-c-Cbl pathway and consequently inhibits osteoclastogenesis and bone destruction in arthritis. [ Cell Death Dis, 2019, 10(2):38] | PubMed: 30674869 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.