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Technical Data
| Formula | C19H18O3 |
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| Molecular Weight | 294.34 | CAS No. | 568-72-9 | |
| Solubility (25°C)* | In vitro | DMSO | 5 mg/mL (16.98 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Tanshinone IIA (Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases; A natural monoacylglycerol lipase inhibitor. | |
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| In vitro | Tanshinone IIA (Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases. Tanshinone IIA protects cardiac myocytes against oxidative stress-induced apoptosis. The in vivo protection is mediated by increased scavenging of oxygen free radicals, prevention of lipid peroxidation and upregulation of the Bcl-2/Bax ratio. [1] Recently, tanshinone IIA was demonstrated to induce cell death and apoptosis in a variety of tumors. [2] | |
| In vivo | LD50: Rats 25g/kg (i.g.) [3] |
Protocol (from reference)
References
Customer Product Validation
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Data from [Data independently produced by , , Cancer Lett, 2017, 403:86-97]
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Data from [Data independently produced by , , Biomed Pharmacother, 2018, 105:758-765]
Selleck's Tanshinone IIA has been cited by 18 publications
| Tanshinone IIA inhibits cell viability and promotes PUMA-mediated apoptosis of oral squamous cell carcinoma [ J Cancer, 2023, 14(13):2481-2490] | PubMed: 37670974 |
| Tanshinone IIA inhibits cell viability and promotes PUMA-mediated apoptosis of oral squamous cell carcinoma [ J Cancer, 2023, 14(13):2481-2490] | PubMed: 37670974 |
| Tan IIA mitigates vascular smooth muscle cell proliferation and migration induced by ox-LDL through the miR-137/TRPC3 axis [ Kaohsiung J Med Sci, 2023, 10.1002/kjm2.12663] | PubMed: 36912285 |
| Tanshinone IIA regulates expression of glucose transporter 1 via activation of the HIF‑1α signaling pathway [ Mol Med Rep, 2022, 26(5)328] | PubMed: 36069225 |
| Tanshinone IIA enhances the ovarian reserve and attenuates ovarian oxidative stress in aged mice [ Vet Med Sci, 2022, 10.1002/vms3.811] | PubMed: 35451235 |
| Tanshinone IIA regulates microRNA‑125b/foxp3/caspase‑1 signaling and inhibits cell viability of nasopharyngeal carcinoma [ Mol Med Rep, 2021, 23(5)371] | PubMed: 33760137 |
| Tanshinone IIA protects human coronary artery endothelial cells from ferroptosis by activating the NRF2 pathway [ Biochem Biophys Res Commun, 2021, 575:1-7] | PubMed: 34454174 |
| Tanshinone IIA Inhibits Epithelial-to-Mesenchymal Transition Through Hindering β-Arrestin1 Mediated β-Catenin Signaling Pathway in Colorectal Cancer [ Front Pharmacol, 2020, 11:586616] | PubMed: 33192529 |
| Tanshinone IIA Suppresses Proliferation and Inflammatory Cytokine Production of Synovial Fibroblasts From Rheumatoid Arthritis Patients Induced by TNF-α and Attenuates the Inflammatory Response in AIA Mice [ Front Pharmacol, 2020, 15;11:568] | PubMed: 32499694 |
| Inhibition of EGFR Signaling and Activation of Mitochondrial Apoptosis Contribute to Tanshinone IIA-Mediated Tumor Suppression in Non-Small Cell Lung Cancer Cells. [ Onco Targets Ther, 2020, 2;13:2757-2769] | PubMed: 32308411 |
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.