Osthole

Catalog No.S2337 Batch:S233703

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Technical Data

Formula

C15H16O3
Molecular Weight 244.29 CAS No. 484-12-8
Solubility (25°C)* In vitro DMSO 49 mg/mL (200.58 mM)
Ethanol 49 mg/mL (200.58 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Osthol is an O-methylated coumarin, which is found in the plants such as Cnidium monnieri, Angelica archangelica and Angelica pubescens.
In vitro Osthol is an O-methylated coumarin which is found in the plants such as Cnidium monnieri, Angelica archangelica and Angelica pubescens. Osthol inhibites platelet aggregation and ATP release induced by ADP, arachidonic acid, PAF, collagen, ionophore A23187 and thrombin in washed rabbit platelets. [1] Osthole mediates cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells and may be a promising agent for treating osteoporosis. [2] Osthole also suppresses the secretion of hepatitis B virus in cell culture by increasing the glycosylation of HBsAg. [3]
In vivo LD50: Rats >125mg/kg (i.v.); Rabbits >35mg/kg (i.v.); Dogs >150mg/kg (i.v.). [4]

Protocol (from reference)

Customer Product Validation

, , Free Radic Biol Med, 2014, 73:260-9.

, , J Biomed Sci, 2015, 22:63.

Selleck's Osthole has been cited by 7 publications

Osthole Inhibits M1 Macrophage Polarization and Attenuates Osteolysis in a Mouse Skull Model [ Oxid Med Cell Longev, 2023, 2023:2975193] PubMed: 36686380
Coumarins of Lovage Roots (Levisticum officinale W.D.J.Koch): LC-MS Profile, Quantification, and Stability during Postharvest Storage [ Metabolites, 2022, 13(1)3] PubMed: 36676932
An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447] PubMed: 30900754
Xanthohumol inhibits colorectal cancer cells via downregulation of Hexokinases II-mediated glycolysis. [ Int J Biol Sci, 2019, 15(11):2497-2508] PubMed: 31595166
Osthole ameliorates hepatic fibrosis and inhibits hepatic stellate cell activation [Liu YW, et al. J Biomed Sci, 2015, 22:63] PubMed: 26231226
Osthole improves an accelerated focal segmental glomerulosclerosis model in the early stage by activating the Nrf2 antioxidant pathway and subsequently inhibiting NF-κB-mediated COX-2 expression and apoptosis [Yang SM， et al. Free Radic Biol Med, 2014, 73:260-9] PubMed: 24858719
Characterization of glycosaminoglycan interaction sites and exosite inhibitors of cathepsin K [Haoran Cui, et al. Shandong University, 2014, Haoran Cui]

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.