Oridonin

Catalog No.S2335 Batch:S233503

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Technical Data

Formula

C20H28O6

Molecular Weight 364.43 CAS No. 28957-04-2
Solubility (25°C)* In vitro DMSO 73 mg/mL (200.31 mM)
Ethanol 28 mg/mL (76.83 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Oridonin, a diterpenoid purified from Rabdosia rubescens, is a traditional agent with antitumor, anti-bacterial and anti-inflammatory effects. Oridonin inhibits AKT1 and AKT2 kinase activity with IC50 of 8.4 μM and 8.9 μM, respectively.
Targets
Akt1 [5]
(Cell-free assay)
Akt2 [5]
(Cell-free assay)
8.4 μM 8.9 μM
In vitro

Oridonin effectively inhibites the proliferation of a wide variety of cancer cells including those from prostate (LNCaP, DU145, PC3), breast (MCF-7, MDA-MB231), non-small cell lung (NSCL) (NCI-H520, NCI-H460, NCI-H1299) cancers, acute promyelocytic leukemia (NB4), and glioblastoma multiforme (U118, U138) with ED50s ranging from 1.8 to 7.5 μg/ml. [1] The antitumor activities of Oridonin may due to its inhibitory effects on NF-kappaB and MAPKs signal pathways. [2] [3]

In vivo

LD50: Mice 35-40mg/kg. [4]

Protocol (from reference)

Customer Product Validation

Data from [Data independently produced by , , Int J Mol Sci, 2018, 19(8)]

Selleck's Oridonin has been cited by 22 publications

Oridonin attenuates the progression of atherosclerosis by inhibiting NLRP3 and activating Nrf2 in apolipoprotein E-deficient mice [ Inflammopharmacology, 2023, 31(4):1993-2005] PubMed: 37155118
Network-Based Method to Investigate the Promoted Cell Apoptosis Mechanisms of Oridonin in OSCC through the RNA-Transcriptome [ J Immunol Res, 2023, 2023:5293677] PubMed: 36969496
FBW7-mediated ubiquitination and destruction of PD-1 protein primes sensitivity to anti-PD-1 immunotherapy in non-small cell lung cancer [ J Immunother Cancer, 2022, 10(9)e005116] PubMed: 36104103
Oridonin alleviates hyperbilirubinemia through activating LXRα-UGT1A1 axis [ Pharmacol Res, 2022, 178:106188] PubMed: 35338002
Effect of oridonin on oxylipins in the livers of mice with acute liver injury induced by D-galactosamine and lipopolysaccharide [ Int Immunopharmacol, 2022, 102:108387] PubMed: 34838489
Oridonin attenuates low shear stress-induced endothelial cell dysfunction and oxidative stress by activating the nuclear factor erythroid 2-related factor 2 pathway [ BMC Complement Med Ther, 2022, 22(1):180] PubMed: 35799227
Oridonin Relieves Angiotensin II-Induced Cardiac Remodeling via Inhibiting GSDMD-Mediated Inflammation [ Cardiovasc Ther, 2022, 2022:3167959] PubMed: 35360548
ASC deglutathionylation is a checkpoint for NLRP3 inflammasome activation [ J Exp Med, 2021, 218(9)e20202637] PubMed: 34342641
Eryptosis and Malaria: New Experimental Guidelines and Re-Evaluation of the Antimalarial Potential of Eryptosis Inducers [ Front Cell Infect Microbiol, 2021, 11:630812] PubMed: 33777843
Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin [ J Nat Prod, 2021, 10.1021/acs.jnatprod.0c01231] PubMed: 33890470

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.