Nanchangmycin

Catalog No.S1450 Batch:S145003

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Technical Data

Formula

C48H80O13
Molecular Weight 889.1 CAS No. 65101-87-3
Solubility (25°C)* In vitro DMSO 100 mg/mL (112.47 mM)
Ethanol 100 mg/mL (112.47 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Nanchangmycin is a polyether antibiotic with similar structure to dianemycin and is very active against a broad spectrum of harmful nematodes and insects but not for mammals and plants.
In vitro Nanchangmycin inhibits gram-positive bacteria. [1]
In vivo Nanchangmycin can be used as a growth promotant in poultry and to cure coccidiosis in chickens[1]. Nanchangmycin is a bacterially-derived natural product that potently blocked ZIKV infection across diverse cell types. It blocks ZIKV entry, as well as DENV infection[2].
Features Polyether antibiotic produced by Streptomyces nanchangensis NS3226.

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    U2OS

  • Concentrations

    0.7 μM

  • Incubation Time

    1 h

  • Method

    5000 cells were plated in 25ul media per well in 384-well plates. The next day, 50 nl of drugs were transfered to each well for a final concentration of 0.7uM/0.2% DMSO in U2OS. The drug treated U2OS cells were infected with Zika MR766, MOI=0.125 and fixed at 48 hours post infection (hpi).

Selleck's Nanchangmycin has been cited by 6 publications

Nanchangmycin regulates FYN, PTK2, and MAPK1/3 to control the fibrotic activity of human hepatic stellate cells [ Elife, 2022, 11e74513] PubMed: 35617485
Identification of Estrogen Receptor Modulators as Inhibitors of Flavivirus Infection [ Antimicrob Agents Chemother, 2020, 1;AAC.00289-20] PubMed: 32482672
Epithelial to mesenchymal transition is mediated by both TGF-β canonical and non-canonical signaling during axolotl limb regeneration [ Sci Rep, 2019, 9(1):1144] PubMed: 30718780
Genome-Wide Mutagenesis of Dengue Virus Reveals Plasticity of the NS1 Protein and Enables Generation of Infectious Tagged Reporter Viruses. [ J Virol, 2017, 91(23)] PubMed: 28956770
Development and validation of a multi-residue screening method for veterinary drugs, their metabolites and pesticides in meat using liquid chromatography-tandem mass spectrometry [Wei H Food Addit Contam Part A Chem Anal Control Expo Risk Assess, 2015, 32(5):686-701] PubMed: 25632989
Development and validation of a multi-residue screening method for veterinary drugs, their metabolites and pesticide in meat using liquid chromatography - tandem mass spectrometry. [Wei H, et al. Food Addit Contam Part A Chem Anal Control Expo Risk Assess, 2015, 10.1080/19440049.2015.1008588] PubMed: 25632989

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.