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Technical Data
| Formula | C12H16O4S2 |
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| Molecular Weight | 288.38 | CAS No. | 59937-28-9 | |
| Solubility (25°C)* | In vitro | DMSO | 58 mg/mL (201.12 mM) | |
| Ethanol | 58 mg/mL (201.12 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Malotilate (NKK105) is a drug used for the treatment of liver cirrhosis. Malotilate is a liver protein metabolism improved compound, which selectively inhibit the 5-lipoxygenase. |
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| In vitro | Malotilate at concentrations of 0.1–100 μM increases collagenase activity in a concentration-dependent manner in the multilayered cultures, but not in the monolayers. Malotilate increases the secretion of MMP-1 and MMP-3 in the wounded multilayered cultures, but not in the wounded monolayers. [1] Malotilate significantly reduces the invasion of the RLE monolayer by c-SST-2 cells. Malotilate prevents the increase in permeability of the RLE monolayer by serum starvation. Malotilate suppresses tumour metastasis by intensifying the cell-to-cell contact of endothelial cells, thus preventing tumour cells from invading vascular endothelium. [2] |
| In vivo | Malotilate suppresses pulmonary metastasis and lung metastasis in rats. [2] Malotilate prevents increases in serum markers of type III and IV collagen synthesis as well as accumulation of the collagens, laminin and fibronectin in the liver of rats. [3] Malotilate combined with CCl4 significantly decreases hydroxyproline accumulation in the liver of rat, liver prolyl 4-hydroxylase and liver and serum galactosylhydroxylysyl glucosyltransferase activities. Malotilate is also able to prevent the development of morphological changes in the liver of rats such as focal necrosis, fatty infiltration and inflammatory changes. Malotilate also normalizes almost completely the standard liver-function tests. [4] Malotilate decreases CYP2E1 levels and increases CYP2B1 levels in hepatic microsomes of rats, while CYP1A expression is not changed. [5] |
Protocol (from reference)
References
Selleck's Malotilate has been cited by 2 publications
| Inhibiting 5-lipoxygenase prevents skeletal muscle atrophy by targeting organogenesis signalling and insulin-like growth factor-1 [ J Cachexia Sarcopenia Muscle, 2022, 13(6):3062-3077] | PubMed: 36221153 |
| Inhibiting 5-lipoxygenase prevents skeletal muscle atrophy by targeting organogenesis signalling and insulin-like growth factor-1 [ J Cachexia Sarcopenia Muscle, 2022, 13(6):3062-3077] | PubMed: 36221153 |
RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.