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Technical Data
| Formula | C19H16ClNO4 |
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| Molecular Weight | 357.79 | CAS No. | 53-86-1 | |
| Solubility (25°C)* | In vitro | DMSO | 72 mg/mL (201.23 mM) | |
| Ethanol | 24 mg/mL (67.07 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Indomethacin is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively, used to reduce fever, pain, stiffness, and swelling. | ||||
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| Targets |
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| In vitro | Indomethacin inhibits transcription of a beta-catenin/TCF-responsive reporter gene in a dose dependent manner. Indomethacin also downregulates the beta-catenin/TCF transcriptional target cyclin D1. Indomethacin attenuates the transcription of beta-catenin/TCF-responsive genes, by modulating TCF activity without disrupting beta-catenin/TCF complex formation. [1] | ||||
| In vivo | Indomethacin increases BrdU+ cells of all lineages and reduces microglial/monocyte activation in rats after focal cerebral ischemia. [2] Indomethacin (7.5 mg/kg, one injection) produces acute injury and inflammation in the distal jejunum and proximal ileum that are maximal at three days and completely resolves within one week. Indomethacin (two daily subcutaneous injections) produces a more extensive and chronic inflammation that lasts in an active form in more than 75% of the rats for at least two weeks. [3] Indomethacin (4ppm) reduces tumor yield by 78% in SKH:HR-1-hrBr hairless mice. [4] Indomethacin (20 mg/kg, orally) increases the total area of gastric erosions and concentration of lipid peroxides in the gastric mucosa of rats. Indomethacin increases the alpha-tocopherol:total cholesterol ratio in serum. Indomethacin inhibits the increases in gastric mucosal erosions and lipid peroxides in the gastric mucosa, and the reduction of serum alpha-tocopherol. [5] |
Protocol (from reference)
References
Customer Product Validation
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Data from [Data independently produced by , , Nat Commun, 2016, 7:12885]
Selleck's Indomethacin has been cited by 16 publications
| A Novel LncRNA MSTRG.310246.1 Promotes Differentiation and Thermogenesis in Goat Brown Adipocytes [ Genes (Basel), 2023, 14(4)833] | PubMed: 37107590 |
| DHODH inhibition represents a therapeutic strategy and improves abiraterone treatment in castration-resistant prostate cancer [ Research Square, 2023, 10.21203/rs.3.rs-3633354/v1] | PubMed: none |
| Herpes Simplex Virus 1-Induced Ferroptosis Contributes to Viral Encephalitis [ mBio, 2022, e0237022.] | PubMed: 36507835 |
| Arachidonic acid drives adaptive responses to chemotherapy-induced stress in malignant mesothelioma [ J Exp Clin Cancer Res, 2021, 40(1):344] | PubMed: 34727953 |
| The novel indomethacin derivative CZ-212-3 exerts antitumor effects on castration-resistant prostate cancer by degrading androgen receptor and its variants [ Acta Pharmacol Sin, 2021, 10.1038/s41401-021-00738-w] | PubMed: 34321613 |
| Molecular Characterization of an Aquaporin-2 Mutation Causing Nephrogenic Diabetes Insipidus [ Front Endocrinol (Lausanne), 2021, 12:665145] | PubMed: 34512542 |
| Chlorogenic Acid Protects Against Indomethacin-Induced Inflammation and Mucosa Damage by Decreasing Bacteroides-Derived LPS [ Front Immunol, 2020, 11:1125] | PubMed: 32582202 |
| Cross-resistance Among Next Generation Anti-Androgen Drugs Through the AKR1C3/AR-V7 Axis in Advanced Prostate Cancer [ Mol Cancer Ther, 2020, 19;molcanther00152020] | PubMed: 32430485 |
| Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation. [ Nat Commun, 2019, 10(1):2427] | PubMed: 31160593 |
| AKR1C3 promotes AR-V7 protein stabilization and confers resistance to AR-targeted therapies in advanced prostate cancer. [ Mol Cancer Ther, 2019, 10.1158/1535-7163] | PubMed: 31308078 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.