Fenofibrate

Catalog No.S1794 Batch:S179405

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Technical Data

Formula

C20H21ClO4

Molecular Weight 360.83 CAS No. 49562-28-9
Solubility (25°C)* In vitro DMSO 72 mg/mL (199.53 mM)
Ethanol 72 mg/mL (199.53 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Fenofibrate is a compound of the fibrate class and fibric acid derivative. Fenofibrate is a selective agonist of PPARα with EC50 of 30 μM. Fenofibrate binds to and inhibits cytochrome P450 epoxygenase (CYP)2C with IC50 of 0.2 μM, 0.7 μM and 9.7 μM for CYP2C19, CYP2B6 and CYP2C9, respectively. Fenofibrate induces autophagy.
Targets
PPARα [1] CYP2C19 [3]
(Cell-free assay)
CYP2B6 [3]
(Cell-free assay)
CYP2C9 [3]
(Cell-free assay)
0.2 μM 0.7 μM 9.7 μM

Protocol (from reference)

Customer Product Validation

Data from [Data independently produced by , , Diabetes, 2017, 66(9):2387-2399]

Data from [Data independently produced by , , Food Funct, 2018, 9(12):6608-6617]

Selleck's Fenofibrate has been cited by 14 publications

EDARADD promotes colon cancer progression by suppressing E3 ligase Trim21-mediated ubiquitination and degradation of Snail [ Cancer Lett, 2023, 10.1016/j.canlet.2023.216427] PubMed: 37838280
Erythrocyte transglutaminase-2 combats hypoxia and chronic kidney disease by promoting oxygen delivery and carnitine homeostasis [ Cell Metab, 2022, 34(2):299-316.e6] PubMed: 35108516
Repositioning Fenofibrate to Reactivate p53 and Reprogram the Tumor-Immune Microenvironment in HPV+ Head and Neck Squamous Cell Carcinoma [ Cancers (Basel), 2022, 14(2)282] PubMed: 35053444
Pharmaceutical targeting of succinate dehydrogenase in fibroblasts controls bleomycin-induced lung fibrosis [ Redox Biol, 2021, 46:102082] PubMed: 34343908
The Cordyceps militaris-Derived Polysaccharide CM1 Alleviates Atherosclerosis in LDLR(-/-) Mice by Improving Hyperlipidemia [ Front Mol Biosci, 2021, 8:783807] PubMed: 34966782
The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies [ Cancer Discov, 2020, CD-20-0160] PubMed: 32703768
The marine-derived furanone reduces intracellular lipid accumulation in vitro by targeting LXRα and PPARα [ J Cell Mol Med, 2020, 24(6):3384-3398] PubMed: 31981312
The marine-derived furanone reduces intracellular lipid accumulation in vitro by targeting LXRα and PPARα. [ J Cell Mol Med, 2020, 24(6):3384-3398] PubMed: 31981312
Efficacy and Mechanism of a Chinese Classic Prescription of Yueju in Treating Nonalcoholic Steatohepatitis and Protecting Hepatocytes from Apoptosis [ Evid Based Complement Alternat Med, 2020, 2020:8888040] PubMed: 33178326
The fucoidan A3 from the seaweed Ascophyllum nodosum enhances RCT-related genes expression in hyperlipidemic C57BL/6J mice. [ Int J Biol Macromol, 2019, 134:759-769] PubMed: 31100394

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.