Calcifediol

Catalog No.S1469 Batch:S146903

Technical Data

Formula	C₂₇H₄₄O₂
Molecular Weight	400.64	CAS No.	19356-17-3
Solubility (25°C)*	In vitro	DMSO	80 mg/mL (199.68 mM)
		Ethanol	80 mg/mL (199.68 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description	Calcifediol (Calcidiol, Didrogyl, Hidroferol, 25-hydroxyvitamin D3, 25-Hydroxycholecalciferol) is a major circulating metabolite of vitamin D3 and acts as a competitive inhibitor with an apparent Ki of 3.9 μM. It also suppresses PTH secretion and mRNA (ED50=2 nM).

Protocol (from reference)

Customer Product Validation

: Data from [Data independently produced by , , Br J Pharmacol, 2017, 174(16):2636-2651]

Selleck's Calcifediol has been cited by 13 publications

Vitamin D supplementation is effective for olanzapine-induced dyslipidemia [ Front Pharmacol, 2023, 14:1135516]	PubMed: 36895943
Vitamin D3 suppresses the cholesterol homeostasis pathway in patient-derived glioma cell lines [ FEBS Open Bio, 2023, 13(9):1789-1806]	PubMed: 37489660
Vitamin D3 suppresses the cholesterol homeostasis pathway in patient-derived glioma cell lines [ FEBS Open Bio, 2023, 13(9):1789-1806]	PubMed: 37489660
FDA-Approved Drug Screening for Compounds That Facilitate Hematopoietic Stem and Progenitor Cells (HSPCs) Expansion in Zebrafish [ Cells, 2021, 10(8)2149]	PubMed: 34440919
Vitamin D Regulates MerTK-Dependent Phagocytosis in Human Myeloid Cells [ J Immunol, 2020, ji2000129]	PubMed: 32540991
Vitamin D 3 Modulates Yellow Catfish (Pelteobagrus Fulvidraco) Immune Function in Vivo and in Vitro and This Involves the Vitamin D 3/VDR-type I Interferon Axis [ Dev Comp Immunol, 2020, 107:103644]	PubMed: 32061641
Roles of Vitamin D and Its Receptor in the Proliferation and Apoptosis of Luteinised Granulosa Cells in the Goat [ Reprod Fertil Dev, 2020, 32(3):335-348]	PubMed: 31708013
1,25‑Dihydroxyvitamin D3 enhances the susceptibility of anaplastic thyroid cancer cells to adriamycin‑induced apoptosis by increasing the generation of reactive oxygen species [ Mol Med Rep, 2019, 20(3):2641-2648]	PubMed: 31524258
Temperature-dependent vitamin D signaling regulates developmental trajectory associated with diapause in an annual killifish [ Proc Natl Acad Sci U S A, 2018, 115(50):12763-12768]	PubMed: 30446615
Potential Use of 1-25-dihydroxyvitamin D in the Diagnosis and Treatment of Papillary Thyroid Cancer [ Med Sci Monit, 2018, 24:1614-1623]	PubMed: 29553126

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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