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How to Cite 1. For In-Text Citation (Materials & Methods): 2. For Key Resources Table: |
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Technical Data
| Formula | C18H22O3 |
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| Molecular Weight | 286.37 | CAS No. | 3131-23-5 | |
| Solubility (25°C)* | In vitro | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | 4-Hydroxyestrone (4-OHE1), an endogenous estrone metabolite formed via CYP1B1 hydroxylation, acts as a potent neuroprotectant against glutamate-induced oxidative toxicity in HT22 cells by inducing SIRT1-mediated deacetylation of phosphorylated p53, promoting its cytoplasmic retention and suppressing pro-apoptotic gene transcription. |
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Protocol (from reference)
References
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