2,3-Dihydroxybenzoic acid

Catalog No.S4946 Batch:S494601

Technical Data

Formula	C₇H₆O₄
Molecular Weight	154.12	CAS No.	303-38-8
Solubility (25°C)*	In vitro	DMSO	30 mg/mL (194.65 mM)


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description	2,3-Dihydroxybenzoic acid (Pyrocatechuic acid, 3-Hydroxysalicylic acid, Hypogallic acid) is a natural phenol found in Phyllanthus acidus and in the aquatic fern Salvinia molesta, also a product of human aspirin metabolism. It is a potentially useful iron-chelating drug and has antimicrobial properties.
In vivo	2,3-dihydroxyhenzoic acid (2,3-DHB) is an orally effective iron-chelating agent in hypertransfused rat. The iron excreted in response tc 2,3-DHB is excreted via the urine. The oral administration of 2,3-DHB decreases time absorption of iron (⁵⁹FeCl₃) by the gut. The LD5O of 2,3-DHB is greater than 3 g/kg in the rabbit. Rats and mice administered up to 600 mg/kg chronically have shown no signs of toxicity^[1].

Description

2,3-Dihydroxybenzoic acid (Pyrocatechuic acid, 3-Hydroxysalicylic acid, Hypogallic acid) is a natural phenol found in Phyllanthus acidus and in the aquatic fern Salvinia molesta, also a product of human aspirin metabolism. It is a potentially useful iron-chelating drug and has antimicrobial properties.

In vivo

2,3-dihydroxyhenzoic acid (2,3-DHB) is an orally effective iron-chelating agent in hypertransfused rat. The iron excreted in response tc 2,3-DHB is excreted via the urine. The oral administration of 2,3-DHB decreases time absorption of iron (⁵⁹FeCl₃) by the gut. The LD5O of 2,3-DHB is greater than 3 g/kg in the rabbit. Rats and mice administered up to 600 mg/kg chronically have shown no signs of toxicity^[1].

Protocol (from reference)

Animal Study:^{^[1]}	Animal Models iron-overloaded rat (Sprague-Dawley rats) Dosages 100 mg/kg Administration orally

References

[1] J. H. Graziano, et al. Journal of Pharmacology and Experimental Therapeutics. 1974, 190(3):570-575.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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