Mdm2 Selective Inhibitors | Antagonists
|Catalog No.||Product Name||Information||Selective / Pan||IC50 / Ki|
MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.
|Selective||MDM2, IC50: 0.88 nM|
Nutlin-3a, the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM.
|Selective||p53/MDM2 interaction, IC50: 90 nM|
Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM; stabilizes p73 in p53-deficient cells.
|Selective||Mdm2, IC50: 90 nM|
Nutlin-3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 μM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.
|Selective||Mdm2, IC50: 13.6 μM|
YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.
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