• γ secretase
  • Notch

Aβ Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S1262 Avagacestat (BMS-708163) Avagacestat (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2. Selective γ secretase(Aβ42), IC50: 0.27 nM; γ secretase(Aβ40), IC50: 0.3 nM
S2215 DAPT (GSI-IX) DAPT (GSI-IX, LY-374973) is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells. DAPT enhances the apoptosis of human tongue carcinoma cells and regulates autophagy. Selective γ secretase(Aβ), IC50: 20 nM
S2660 MK-0752 MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM. Phase 1/2. Selective
S1594 Semagacestat (LY450139) Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, also inhibits Notch signaling with IC50 of 14.1 nM in H4 human glioma cell. Phase 3. Pan γ secretase(Aβ42), IC50: 10.9 nM; γ secretase(Aβ40), IC50: 12.1 nM; γ secretase(Aβ38), IC50: 12.0 nM