P P P P P P P P P P P P Ub Ub Ub Ub P IntracellularVesicle PI3K APC Smo Akt Hedgehog PKA GSK-3β GSK-3β GSK-3β PKC JNK HDAC STAT3 TAK2 STAT3 STAT3 MAPK Caspase-3 STAT3 Smad1 Smad4 Smad1 Smad4 FGFR β-cat β-cat β-cat β-cat TGFβ Wnt Rac BMP SUFU GRK CKI Axin Axin αi α γ Gli Gli NFAT API β γ β DSH Rho PLC SHARP SMRT CtBp Nicd CSL Nicd CSL Hes1 Hes1 LIF Cdx2 Gata6 Others Ronin P300 Mam TCF/LEF α (cAMP) Ca 2+ PTC Frizzled GTP GTP GTP γ-Secretase Proteasome LIFR gp130 FGF Gfap Idl Translocation S2 ADAM17 Sanpodo TGFβRⅠ,TGFβRⅡ Gene Expression E(Spl) Hey Herp2 Hey Hes1 Hey1 Hes1 Dll1,3,4/Jagged1,2 Hedgehog InhibitorsCyclopamineVismodegib Smoothened AntagonistsCyclopamineSonidegibSmoothened AgonistsSmoothened Agonist (SAG)Purmorphamine Pan-TGF-beta/Smad InhibitorsLDN-193189K02288Selective TGF-beta/Smad InhibitorsSB431542 (ALK5)Galunisertib (TGF-βRI) GSK-3β InhibitorsTWS119TideglusibAR-A014418 Gamma-secretaseInhibitorsDAPTRO4929097CrenigacestatLY411575DibenzazepineNirogacestat Pan-STAT InhibitorSH-4-54Selective STAT InhibitorsFludarabine (STAT1)Stattic (STAT3)C188-9 (STAT3)AS1517499 (STAT6) Wnt InhibitorsXAV-939IWR-1-endoIWP-2Wnt-C59ICG-001LGK-974PRI-724Wnt AgonistsSKL2001Wnt agonist 1 Wnt InhibitorsXAV-939IWR-1-endoIWP-2Wnt-C59ICG-001LGK-974PRI-724Wnt AgonistsSKL2001Wnt agonist 1 Ub Ub Ub Ub P Ub {{ board.text }} PTC Dll1,3,4/Jagged1,2 Frizzled ADAM17 Sanpodo S2 LIFR gp130 FGF Gene Expression Herp2 Hey Hey Hes1 Hes1 Hey1 E(Spl) Gfap Idl GTP GTP GTP (cAMP) Ca 2+ TGFβR I, TGFβR II Intracellular Vesicle Translocation {{ board.text }} {{ board.text }} {{ group.title }} {{ text.text }} {{ button.text }} P P P P {{ group.title }} {{ text.text }} Notes: 1:Clickable 2:Unclickable