Stachydrine hydrochloride

Catalog No.S3760

For research use only.

Stachydrine is isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits. It has potent anti-metastatic activity and cardioprotective effects. Stachydrine hydrochloride is the major active constituent of Herba Leonuri, which is a potential therapy for cardiovascular diseases. Stachydrine can inhibit the NF-κB signal pathway. Anti-hypertrophic activities.

Stachydrine hydrochloride Chemical Structure

CAS No. 4136-37-2

Purity & Quality Control

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Biological Activity

Description Stachydrine is isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits. It has potent anti-metastatic activity and cardioprotective effects. Stachydrine hydrochloride is the major active constituent of Herba Leonuri, which is a potential therapy for cardiovascular diseases. Stachydrine can inhibit the NF-κB signal pathway. Anti-hypertrophic activities.
Targets
NF-κB [4]
()
In vitro

Stachydrine could protect the renal tubular epithelial cell from hydrogen peroxide-induced damage[1]. Stachydrine significantly inhibits chemokine receptors activity in PC-3 and LNcaP cell lines in a dose dependent manner[2].

In vivo

Stachydrine possesses a strong anticancer activity, hypoglycemic and in cardiovascular diseases. Its treatment significantly decreases the infract volume and apoptosis ratio in cerebral ischemic neonatal rat, which confirms its neuroprotective effect. Stachydrine also decreases oxidative stress and alters the level of brain cytokine. It also decreases the HDAC activity and improves the expression of H3 and H4 proteins in brain tissues of cerebral ischemic neonatal rats.

Protocol (from reference)

Cell Research:

[2]

  • Cell lines: human prostate cancer cells (PC-3 and LNcaP)
  • Concentrations: 5 μM and 10 μM
  • Incubation Time: 48 h
  • Method:

    Cytotoxicity activity is evaluated by MTT assay. Cells are treated with 5 μM and 10 μM of Stachydrine and positive control (Paclitaxel-1 μM and 5 μM) for 48 h.

  • (Only for Reference)
Animal Research:

[1]

  • Animal Models: Wistar male rats
  • Dosages: 0.52, 0.26 and 0.13 mM/kg/day
  • Administration: by gastric lavage
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 35 mg/mL
(194.83 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 179.64
Formula

C7H14NO2.Cl

CAS No. 4136-37-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C[N+]1(CCCC1C(=O)O)C.[Cl-]

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