Hexachlorophene

Catalog No.S4632 Synonyms: Hexachlorofen, Fostril, Nabac, pHisoHex

Hexachlorophene Chemical Structure

Molecular Weight(MW): 406.90

Hexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 μM; It can also attenuate Wnt/beta-catenin signaling through the Siah-1-mediated beta-catenin degradation.

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Biological Activity

Description Hexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 μM; It can also attenuate Wnt/beta-catenin signaling through the Siah-1-mediated beta-catenin degradation.
Targets
KCNQ1/KCNE1 [1]
(CHO cells)
4.61 μM(EC50)
In vitro

Hexachlorophene, the active component of a prescription drug, as a potent KCNQ channel activator with unique subtype selectivity. It exhibits strong potentiation effects on both the homomeric KCNQ1 and the KCNQ1/KCNE1 complex. HCP potently increases the current amplitude of KCNQ1/KCNE1 expressed by stabilizing the channel in an open state with an EC50 of 4.61±1.29 μM. HCP significantly shortens the action potential duration at 1 μM in cardiomyocytes. In addition, HCP is capable of rescuing the loss of function of the LQTs mutants caused by either impaired activation gating or phosphatidylinositol-4,5-bisphosphate (PIP2) binding affinity[1].

Protocol

Solubility (25°C)

In vitro DMSO 81 mg/mL (199.06 mM)
Ethanol 81 mg/mL (199.06 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 406.90
Formula

C13H6Cl6O2

CAS No. 70-30-4
Storage powder
in solvent
Synonyms Hexachlorofen, Fostril, Nabac, pHisoHex

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Potassium Channel Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID