Home Transmembrane Transporters Potassium Channel activator Hexachlorophene For research use only.

Hexachlorophene

Synonyms: Hexachlorofen, Fostril, Nabac, pHisoHex

Hexachlorophene (Hexachlorofen, Fostril, Nabac, pHisoHex) is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 μM; It can also attenuate Wnt/beta-catenin signaling through the Siah-1-mediated beta-catenin degradation.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.

Hexachlorophene Chemical Structure

Hexachlorophene Chemical Structure

CAS: 70-30-4

Selleck's Hexachlorophene has been cited by 2 publications

Purity & Quality Control

Batch: S463201 DMSO] 81 mg/mL] false] Ethanol] 81 mg/mL] false] Water] Insoluble] false Purity: 99.35%
99.35

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Signaling Pathway

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Potassium Channel Signaling Pathway

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Biological Activity

Description Hexachlorophene (Hexachlorofen, Fostril, Nabac, pHisoHex) is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 μM; It can also attenuate Wnt/beta-catenin signaling through the Siah-1-mediated beta-catenin degradation.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
Targets
KCNQ1/KCNE1 [1]
(CHO cells)
4.61 μM(EC50)
In vitro
In vitro Hexachlorophene, the active component of a prescription drug, as a potent KCNQ channel activator with unique subtype selectivity. It exhibits strong potentiation effects on both the homomeric KCNQ1 and the KCNQ1/KCNE1 complex. HCP potently increases the current amplitude of KCNQ1/KCNE1 expressed by stabilizing the channel in an open state with an EC50 of 4.61±1.29 μM. HCP significantly shortens the action potential duration at 1 μM in cardiomyocytes. In addition, HCP is capable of rescuing the loss of function of the LQTs mutants caused by either impaired activation gating or phosphatidylinositol-4,5-bisphosphate (PIP2) binding affinity[1].

Chemical Information & Solubility

Molecular Weight 406.90 Formula

C13H6Cl6O2
CAS No. 70-30-4 SDF Download Hexachlorophene SDF
Smiles C1=C(C(=C(C(=C1Cl)Cl)CC2=C(C(=CC(=C2Cl)Cl)Cl)O)O)Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 81 mg/mL ( (199.06 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 81 mg/mL

Water : Insoluble


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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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