Pergolide Mesylate

For research use only. Not for use in humans.

Catalog No.S4000 Synonyms: LY127809

3 publications

Pergolide Mesylate Chemical Structure

Molecular Weight(MW): 410.59

Pergolide Mesylate is an antiparkinsonian agent which functions as a dopaminergic agonist.

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 310 In stock
USD 147 In stock
USD 397 In stock
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Biological Activity

Description Pergolide Mesylate is an antiparkinsonian agent which functions as a dopaminergic agonist.
Targets
D2 receptor [1] D1 receptor [1] 5-HT1A [5] 5-HT1B [5] 5-HT2A [5]
In vitro

Pergolide mesylate (trade name Permax) is an ergoline-based dopamine receptor agonist used in some countries for the treatment of Parkinson's disease. Pergolide mesylate functions as an agonist at the dopamine D2, D1 and serotonin 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT2C receptors. It may possess agonist activity at other dopamine receptor subtypes as well, similar to cabergoline. [1][2]

In vivo Pergolide mesylate decreases plasma prolactin concentrations. [3] The weak agonist activity of pergolide at D1 receptors somewhat alters its clinical and side effect profile in the treatment of Parkinson's disease. The drug is in decreasing use, as it is reported to be associated with a form of heart disease called cardiac fibrosis. The use of pergolide or cabergoline is associated with a significantly increased risk of newly diagnosed cardiac-valve regurgitation. [4]

Protocol

Solubility (25°C)

In vitro Water 82 mg/mL (199.71 mM)
DMSO 10 mg/mL (24.35 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 410.59
Formula

C19H26N2S.CH4O3S

CAS No. 66104-23-2
Storage powder
in solvent
Synonyms LY127809
Smiles CCCN1CC(CSC)CC2C1CC3=C[NH]C4=C3C2=CC=C4.C[S](O)(=O)=O

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