Oxymatrine

Catalog No.S2338 Synonyms: Matrine N-oxide

For research use only.

Oxymatrine (Matrine N-oxide) is a quinolizidine alkaloid extracted from the root of Sophora flavescens with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. It is used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage and skin diseases.

Oxymatrine Chemical Structure

CAS No. 16837-52-8

Selleck's Oxymatrine has been cited by 4 Publications

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Biological Activity

Description Oxymatrine (Matrine N-oxide) is a quinolizidine alkaloid extracted from the root of Sophora flavescens with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. It is used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage and skin diseases.
In vitro

Oxymatrine is a quinolizidine alkaloid extracted from the root of Sophora flavescens, which is used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage and skin diseases (such as colpitis, psoriasis and eczema). Oxymatrine protects mice from fulminant hepatitis induced by GalN/LPS and may block hepatocyte apoptosis and subsequent necrosis through downregulating the production of serum tumor necrosis factor alpha and the expression of Fas and Fas ligand in liver tissue. [1] ) Oxymatrine also shows anti-hepatitis B virus effect in vivo by reducing the contents of HBsAg and HBcAg in transgenic mice liver. [2]

In vivo LD50: Mice 521mg/kg (i.p.) [3]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 53 mg/mL
(200.48 mM)
Water 53 mg/mL
(200.48 mM)
Ethanol 53 mg/mL
(200.48 mM)

Chemical Information

Molecular Weight 264.36
Formula

C15H24N2O2

CAS No. 16837-52-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CC2C3CCC[N+]4(C3C(CCC4)CN2C(=O)C1)[O-]

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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