For research use only.
Catalog No.S2290 Synonyms: Dihydroqinghaosu, β-Dihydroartemisinin, Artenimol
CAS No. 71939-50-9
Dihydroartemisinin (DHA, Dihydroqinghaosu, β-Dihydroartemisinin, Artenimol) is a semi-synthetic derivative of artemisinin and isolated from the traditional Chinese herb Artemisia annua. Dihydroartemisinin induces autophagy and apoptosis by suppressing NF-κB activation.
Selleck's Dihydroartemisinin (DHA) has been cited by 15 publications
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In the migration assays, the TCTP-positive cell lines NOZ, GBC-SD, and OCUG-1, and the TCTP-negative cell lines EH-GB-2 and SGC-996 were pre-treated with either vehicle or DHA (40 μM) for 2 days and then seeded in transwell plates for 24 h.
J Exp Clin Cancer Res, 2017, 36(1):68. Dihydroartemisinin (DHA) purchased from Selleck.
Overexpression of GLUT1 inhibits cell death triggered by DHA. A549 and PC-9 cells were transfected with control (Ctr) and GLUT1 vector for 8 h respectively, and then treated with the indicated concentration of DHA for 48 h. (A) Cell lysates were subjected to western blot analysis with the indicated antibodies. (B) Cell growth inhibition activity was assessed by MTT. This experiment was repeated thrice. Columns, mean; bars, SD. ***, P < 0.001.
PLoS One, 2015, 10(3):e0120426.. Dihydroartemisinin (DHA) purchased from Selleck.
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|Description||Dihydroartemisinin (DHA, Dihydroqinghaosu, β-Dihydroartemisinin, Artenimol) is a semi-synthetic derivative of artemisinin and isolated from the traditional Chinese herb Artemisia annua. Dihydroartemisinin induces autophagy and apoptosis by suppressing NF-κB activation.|
Dihydroartemisinin (DHA) inhibits the growth of certain cancer cell lines and xenograft tumors such as leukemia, glioma, fibrosarcoma, and breast, cervical, ovarian, lung, oral and pancreatic cancer. DHA inhibits cell and tumor growth by modulating various tumor-suppressive pathways, such as inhibiting cell proliferation and inducing apoptosis through regulation of proliferation- and apoptosis-related proteins.DHA inhibits the proliferation and viability of cells in a dose-dependent manner and induces apoptosis.DHA-mediated cytotoxicity is tumor selective. The endoperoxide bridge of DHA is reportedly essential for its cytotoxicity because it reacts with intracellular ferrous iron to generate reactive oxygen species or carbon-centered radicals, leading to cytotoxicity.
DHA significantly inhibited HCC cell growth in vitro and in vivo via inducing G2/M cell cycle arrest and apoptosis. DHA has been shown in the rat whole embryo culture (WEC) to primarily affect primitive red blood cells (RBCs) causing subsequent tissue damage and dysmorphogenesis.
|In vitro||DMSO||56 mg/mL warmed (196.94 mM)|
|Ethanol||11 mg/mL warmed (38.68 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||Dihydroqinghaosu, β-Dihydroartemisinin, Artenimol|
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation ()|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03402789||Not yet recruiting||Drug: Docosahexaenoic Acid|Drug: Placebo Oral Tablet||Amblyopia||Johns Hopkins University||January 1 2021||Phase 1|Phase 2|
|NCT04300309||Not yet recruiting||Drug: artemether:lumefantrine (2.5 mg:30 mg)||Plasmodium Falciparum Malaria||Novartis Pharmaceuticals|Medicines for Malaria Venture (MMV) Switzerland|Groupe de Recherche Action en Santé (GRAS) Ouagadougou Burkina Faso|Institut de Recherche en sciences de la Santé - Unité de Recherche Clinique de Nanoro (IRSS-URCN) Burkina Faso|Novartis||January 7 2021||Phase 2|Phase 3|
|NCT04487145||Recruiting||Drug: Dihydroartemisinin-piperaquine||Drug-Drug Interaction|HIV Infection||University of California San Francisco|Yale University|Makerere University|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)||November 23 2020||Phase 4|
|NCT04575753||Recruiting||Other: Study group||Delirium||Université Libre de Bruxelles|CHU de Charleroi||October 7 2020||--|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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