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Technical Data
| Formula | C16H13ClFN3O2 |
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| Molecular Weight | 333.74 | CAS No. | 690206-97-4 | |
| Solubility (25°C)* | In vitro | DMSO | 67 mg/mL (200.75 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | ZM 306416 (CB 676475) is a VEGFR (Flt and KDR) inhibitor for VEGFR1 with IC50 of 0.33 μM, but also found to inhibit EGFR with IC50 of <10 nM. | ||||||
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| In vitro | ZM-306416 induces selective antiproliferative effect toward the EGFR-addicted NSCLC cell lines H3255 and HCC4011 with IC50 of 0.09 µM and 0.072 µM, respectively. ZM-306416 inhibits granule formation with IC50 of 0.67 μM. [1] ZM-306416 significantly inhibits the ERRα assay with IC50 of 7.3 μM in the GeneBLAzer T-Rex RORγ-UAS-bla HEK293T cell line. [2] ZM306416 (300 nM) completely inhibits PAA secretion and stimulates [125]I uptake in human thyroid follicular cells. ZM306416 (300 nM) abolishes pVEGFR2 (Y1214) expression in human thyroid follicular cells. ZM306416 (< 10 μM) has marked inhibitory effects on the steady state phosphorylation of p42/44 MAPK but does not affect the expression of the unphosphorylated form. ZM306416 (3 μM) significantly increases cell death in human thyroid follicular cells. ZM306416 (3 μM) significantly increases cell death in human thyroid follicular cells. ZM306416 weakly inhibits the secretion of VEGF and increases the production of PlGF. [3] ZM306416 (1 μM) enhances follicle formation and decreased nuclear distribution in human thyroid follicular cells. [4] |
Protocol (from reference)
References
Customer Product Validation
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, , Sci Rep, 2015, 5:7890.
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, , Cell Signal, 2016, 28(6):652-62.
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Data from [Data independently produced by , , PLoS One, 2016, 11(9):e0161332]
Selleck's ZM 306416 has been cited by 12 publications
| Regulation of Cell Cycle Progression through RB Phosphorylation by Nilotinib and AT-9283 in Human Melanoma A375P Cells [ Int J Mol Sci, 2024, 25(5)2956] | PubMed: 38474202 |
| Histamine promotes angiogenesis through a histamine H1 receptor-PKC-VEGF-mediated pathway in human endothelial cells [ J Pharmacol Sci, 2023, 151(4):177-186] | PubMed: 36925216 |
| Establishment of an oral squamous cell carcinoma cell line expressing vascular endothelial growth factor a and its two receptors [ J Dent Sci, 2022, 17(4):1471-1479] | PubMed: 36299342 |
| Vascular endothelial growth factor B exerts lipid-lowering effect by activating AMPK via VEGFR1 [ Life Sci, 2021, 276:119401] | PubMed: 33785341 |
| Crizotinib and Doxorubicin Cooperatively Reduces Drug Resistance by Mitigating MDR1 to Increase Hepatocellular Carcinoma Cells Death [ Front Oncol, 2021, 11:650052] | PubMed: 34094940 |
| The in vitro effect of VEGF receptor inhibition on primary alveolar osteoblast nodule formation. [ Aust Dent J, 2020, 10.1111/adj.12752] | PubMed: 32072641 |
| Central VEGF-A pathway plays a key role in the development of trigeminal neuropathic pain in rats. [ Mol Pain, 2019, 15:1744806919872602] | PubMed: 31397622 |
| Activated T cells induce proliferation of oligodendrocyte progenitor cells via release of vascular endothelial cell growth factor-A. [ Glia, 2018, 66(11):2503-2513] | PubMed: 30500113 |
| Vasculogenic and angiogenic potential of adipose stromal vascular fraction cell populations in vitro [Zakhari JS In Vitro Cell Dev Biol Anim, 2018, 54(1):32-40] | PubMed: 29197029 |
| Cooperative Effects of Vascular Angiogenesis and Lymphangiogenesis [ Regen Eng Transl Med, 2018, 4(3):120-132] | PubMed: 30417074 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.