ZL0420

Catalog No.S8763 Batch:S876301

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Technical Data

Formula

C16H16N4O2

Molecular Weight 296.32 CAS No. 2229039-45-4
Solubility (25°C)* In vitro DMSO 59 mg/mL (199.1 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description ZL0420 is a potent and selective BRD4 inhibitor with IC50 values of 27 nM against BRD4 BD1 and 32 nM against BRD4 BD2 respectively and good selectivity over that of the related BRD2 homolog.
Targets
BRD4 BD1 [1]
(Cell-free assay)
BRD4 BD2 [1]
(Cell-free assay)
27 nM 32 nM
In vitro

ZL0420 has a relatively high clearance and low exposures with oral bioavailability not favorable in vivo. Intravenous administration of ZL0420 gives an excellent drug exposure (high AUC value) and moderate half-life[1].

Protocol (from reference)

Animal Study:

[1]

  • Animal Models

    Male C57BL6/J mice (12 weeks old)

  • Dosages

    10 mg/kg

  • Administration

    i.p.

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.