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Technical Data
| Formula | C17H13Cl2NO4 |
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| Molecular Weight | 366.20 | CAS No. | 1037184-44-3 | |
| Solubility (25°C)* | In vitro | DMSO | 73 mg/mL (199.34 mM) | |
| Ethanol | 51 mg/mL (139.26 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | YK-4-279 is a potent inhibitor of EWS-FLI1 binding to RNA helicase A (RHA). | ||
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| In vitro | YK-4-279 eliminates cyclin D levels by blocking the interaction of EWS-FLI1 with RHA in EWS-FLI1-containing TC32 cells. YK-4-279 also specifically inhibits ESFT cell growth and induces apoptosis. [1] YK-4-279 also inhibits ERG and ETV1 biological activity in fusion-positive prostate cancer cells, and further decreases cell motility and invasion. [2] | ||
| In vivo | In vivo, YK-4-279 (1.5 mg/dose i.p.) inhibits the growth of ESFT xenograft tumors. [1] In mouse model, YK-4-279 selectively prevents prostate cancer growth and metastasis in fusion-positive LNCaP-luc-M6 tumors. [3] |
Protocol (from reference)
| Animal Study:[1] |
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References
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Customer Product Validation
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Data from [Data independently produced by , , Oncotarget, 2017, 8(55):94780-94792]
Selleck's YK-4-279 has been cited by 13 publications
| High-Content and High-Throughput Clonogenic Survival Assay Using Fluorescence Barcoding [ Cancers -Basel), 2023, 15(19)4772] | PubMed: 37835466 |
| TK216 targets microtubules in Ewing sarcoma cells [ Cell Chem Biol, 2022, 29(8):1325-1332.e4] | PubMed: 35803262 |
| The ETS Inhibitor YK-4-279 Suppresses Thyroid Cancer Progression Independent of TERT Promoter Mutations [ Front Oncol, 2021, 11:649323] | PubMed: 34221969 |
| Telomerase Reverse Transcriptase Promoter Mutations Identify a Genomically Defined and Highly Aggressive Human Pleural Mesothelioma Subgroup [ Clin Cancer Res, 2020, 26(14):3819-3830] | PubMed: 32317288 |
| Telomerase Reverse Transcriptase Promoter Mutations Identify a Genomically Defined and Highly Aggressive Human Pleural Mesothelioma Subgroup [ Clin Cancer Res, 2020, 21;clincanres35732019] | PubMed: 32317288 |
| p53 Loss Mediates Hypersensitivity to ETS Transcription Factor Inhibition Based on PARylation-Mediated Cell Death Induction [ Cancers (Basel), 2020, 12(11)E3205] | PubMed: 33143299 |
| Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras. [ Cell, 2019, 36(2):179-193] | PubMed: 28162770 |
| A Pharmacogenomic Landscape in Human Liver Cancers. [ Cancer Cell, 2019, 36(2):179-193] | PubMed: 31378681 |
| Antiviral candidates against the hepatitis E virus (HEV) and their combinations inhibit HEV growth in in vitro. [ Antiviral Res, 2019, 170:104570] | PubMed: 31362004 |
| TERT expression is susceptible to BRAF and ETS-factor inhibition in BRAFV600E/TERT promoter double-mutated glioma. [ Acta Neuropathol Commun, 2019, 7(1):128] | PubMed: 31391125 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.