Toll Free: (877) 796-6397 -- USA and Canada only -- |
Fax: +1-832-582-8590 Orders: +1-832-582-8158 |
Tech Support: +1-832-582-8158 Ext:3 Please provide your Order Number in the email. |
Formula | C14H21N3O |
||||||
Molecular Weight | 247.34 | CAS No. | 146986-50-7 | ||||
Solubility (25°C)* | In vitro | DMSO | 49 mg/mL (198.1 mM) | ||||
Ethanol | 49 mg/mL (198.1 mM) | ||||||
Water | Insoluble | ||||||
In vivo (Add solvents to the product individually and in order) |
|
||||||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Y-27632 is a selective ROCK1 and ROCK2 inhibitor with a Ki of 140 nM and 300nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK. | ||||
---|---|---|---|---|---|
Targets |
|
||||
In vitro | Y-27632 primes human induced pluripotent stem cells (hIPSCs) to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation.[2] |
||||
In vivo | Y27632, a specific inhibitor of ROCK, supresses ROCK as well as altered pathways and leads to a significant enhancement in corneal nerve regeneration.[3] |
Cell Assay: |
|
---|---|
Animal Study: |
|
|
Nongenetic Optical Modulation of Pluripotent Stem Cells Derived Cardiomyocytes Function in the Red Spectral Range [ Adv Sci (Weinh), 2024, 11(3):e2304303] | PubMed: 37948328 |
Targeting EMSY-mediated methionine metabolism is a potential therapeutic strategy for triple-negative breast cancer [ Cell Rep Med, 2024, 5(2):101396] | PubMed: 38290515 |
Auranofin repurposing for lung and pancreatic cancer: low CA12 expression as a marker of sensitivity in patient-derived organoids, with potentiated efficacy by AKT inhibition [ J Exp Clin Cancer Res, 2024, 43(1):88] | PubMed: 38515178 |
Biosafe cerium oxide nanozymes protect human pluripotent stem cells and cardiomyocytes from oxidative stress [ J Nanobiotechnology, 2024, 22(1):132] | PubMed: 38532378 |
Cell mechanics regulate the migration and invasion of hepatocellular carcinoma cells via JNK signaling [ Acta Biomater, 2024, S1742-7061(24)00036-9] | PubMed: 38272199 |
Culture and expansion of murine proximal airway basal stem cells [ Stem Cell Res Ther, 2024, 15(1):26] | PubMed: 38287366 |
Kupffer cells abrogate homing and repopulation of allogeneic hepatic progenitors in injured liver site [ Stem Cell Res Ther, 2024, 15(1):48] | PubMed: 38378583 |
Btbd8 deficiency reduces susceptibility to colitis by enhancing intestinal barrier function and suppressing inflammation [ Front Immunol, 2024, 15:1382661] | PubMed: 38558797 |
The Analysis of Embryoid Body Formation and Its Role in Retinal Organoid Development [ Int J Mol Sci, 2024, 25(3):1444.] | PubMed: 38338722 |
Traces of Canine Inflammatory Bowel Disease Reflected by Intestinal Organoids [ Int J Mol Sci, 2024, 25(1)576] | PubMed: 38203746 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.