VEGFD Rabbit mAb

VEGFD Rabbit mAb recognizes endogenous levels of total VEGFD protein.

Vascular endothelial growth factor-D (VEGF-D), also known as c-fos-induced growth factor (FIGF), is a secreted glycoprotein involved in the growth, remodeling, and maintenance of blood and lymphatic vessels. VEGF-D belongs to the VEGF family and shares the conserved cystine-knot motif, forming either non-covalent or covalent homodimers stabilized by intersubunit disulfide bonds. Each monomer consists of an antiparallel 4-stranded β-sheet, three connecting loops, and an N-terminal α-helix. VEGF-D acts as a ligand for VEGFR-2 and VEGFR-3, receptor tyrosine kinases predominantly expressed on endothelial cells, activating signaling pathways that promote cell proliferation, migration, tube formation, and vascular remodeling. It plays a critical role in pathological angiogenesis and lymphangiogenesis, and is implicated in various diseases including cancer, cardiovascular disorders, ocular diseases, and pulmonary lymphangioleiomyomatosis (LAM), where it serves as a diagnostic biomarker. VEGF-D's expression is regulated by the transcription factor c-Fos and its manipulation offers therapeutic potential in anti-angiogenic strategies and regenerative medicine