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How to Cite 1. For In-Text Citation (Materials & Methods): 2. For Key Resources Table: |
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Technical Data
| Formula | C8H18N2O4S |
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| Molecular Weight | 238.30 | CAS No. | 1034190-08-3 | |
| Solubility (25°C)* | In vitro | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | ALZ-801 is an orally bioavailable small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor. As a valine-conjugated prodrug of tramiprosate, it demonstrates significantly enhanced pharmacokinetic properties and gastrointestinal tolerability compared to the parent compound. This agent represents an optimized therapeutic candidate for Alzheimer's disease treatment. |
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| In vivo | ALZ-801 (oral administration; 172?mg/kg; single dose) exhibits mean AUCt values of 58,758 and? 5841 ng/ml.h in plasma and brain, respectively. The ALZ-801: Tramiprosate ratio in plasma and brain is 1.8 and 3.1, respectively in male CD-1 mice. |
Protocol (from reference)
References
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