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How to Cite 1. For In-Text Citation (Materials & Methods): 2. For Key Resources Table: |
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Technical Data
| Formula | C28H27F2N3O2 |
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| Molecular Weight | 475.53 | CAS No. | 2098585-77-2 | |
| Solubility (25°C)* | In vitro | DMSO | 95 mg/mL (199.77 mM) | |
| Ethanol | 95 mg/mL (199.77 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | TAS1440 is an orally active LSD1/KDM1A inhibitor with a human IC50 of 4.8 nM, that non-covalently binds to the histone H3-binding pocket of LSD1, inhibiting demethylase activity and separately disrupting repressive complexes with INSM1 and SMAD2. TAS1440 activates tumor-suppressive TGF-β and NOTCH signaling pathways via transcriptional reprogramming. TAS1440 can be used for the research of small cell lung cancer, specifically the SCLC-A subtype. |
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Protocol (from reference)
References
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SHIPPING AND STORAGE
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