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Technical Data
| CAS No. | 1491917-83-9 (Sacituzumab govitecan) |
|---|---|
| DAR | 7.6 |
| ADC antiody | Sacituzumab |
| ADC cytotoxin | SN-38 |
| Storage (From the date of receipt) |
Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles. |
| Purity | 98.93% |
| Protein concentration | 10mg/ml |
| Endotoxin Level | ＜1EU/mg |
Biological Activity
| Description | Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38, showing anticancer activity. Sacituzumab govitecan has a molecular weight of 160KDa. This product is supplied as 10mg/ml PBS solution. |
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Selleck's Sacituzumab govitecan Has Been Cited by 5 publications
| Eradicating Drug Tolerant Persister Cells in EGFR-Mutated Non-Small Cell Lung Cancer by Targeting TROP2 with CAR-T cellular therapy [ Cancer Discov, 2025, 10.1158/2159-8290.CD-24-1515] |
https://www.ncbi.nlm.nih.gov/pubmed/?term=40762432 |
| A multicenter study on TROP2 as a potential targeted therapy for extramammary Paget disease in Japan [ Scientific Reports, 2025, 409] |
https://www.ncbi.nlm.nih.gov/pubmed/?term= |
| TROP2 Expression in Salivary Gland Adenoid Cystic Carcinoma (ACC) According to Histologic Subtype: Therapeutic Implications [ J Oral Pathol Med, 2025, 10.1111/jop.70008] |
https://www.ncbi.nlm.nih.gov/pubmed/?term=40624990 |
| TROP2 Expression in Salivary Gland Adenoid Cystic Carcinoma (ACC) According to Histologic Subtype: Therapeutic Implications [ Journal of Oral Pathology & Medicine, 2025, 658-666] |
https://www.ncbi.nlm.nih.gov/pubmed/?term=40624990 |
| TROP2 Expression and Therapeutic Implications in Cutaneous Squamous Cell Carcinoma: Insights From Immunohistochemical and Functional Analysis [ Experimental Dermatology, 2024, e15196] |
https://www.ncbi.nlm.nih.gov/pubmed/?term=39422290 |
FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS.
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products are stable under the recommended conditions. Products are sometimes shipped at a temperature that differs from the recommended storage temperature. Short-term storage of many products are stable in the short-term at temperatures that differ from that required for long-term storage.
We ensure that the product is shipped under conditions that will maintain the quality of the reagents. Upon receipt of the product, follow the storage recommendations on the product data sheet.