S961

Catalog No.S6922 Batch:S692201

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Technical Data

Formula

C211H297N55O71S2
Molecular Weight 4804.13 CAS No. 1083433-49-1
Solubility (25°C)* In vitro DMSO 100 mg/mL (20.81 mM)
Water Insoluble
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description S961 is a biosynthetic insulin receptor antagonist that inhibits cellular proliferation and colony formation in breast tumour cells.
Targets
insulin receptor [1]
In vitro

S961 is a biosynthetic insulin receptor (IR) antagonist that inhibits cellular proliferation.

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    MCF-7, MDA-MB-231 and T47D cells

  • Concentrations

    10 nM

  • Incubation Time

    2 h

  • Method

    Cells were incubated with 1 or 10 nM of S961 for two hours, and then insulin was administered, and after 24 h, IC50 was measured.
Animal Study:

[2]
  • Animal Models

    B6SJL mice

  • Dosages

    10 μg/animal

  • Administration

    i.v.

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.