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Technical Data
| Formula | C13H19NO2 |
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| Molecular Weight | 221.30 | CAS No. | 1956370-21-0 | |
| Solubility (25°C)* | In vitro | DMSO | 44 mg/mL (198.82 mM) | |
| Ethanol | 44 mg/mL (198.82 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | RIPA-56 is a highly-potent, selective, and metabolically stable RIP1 (RIPK1) inhibitor. | ||
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| In vitro | RIPA-56 shows efficient inhibition of RIP1 kinase activity, with an IC50 of 13 nM. It showed no inhibition of RIP3 kinase activity at a 10 µM concentration. RIPA-56 does not inhibit IDO activity at a concentration of 200 µM, which represents an estimated 10,000-fold selectivity window based on the RIP1 ADP-Glo activity of 13 nM[1]. |
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| In vivo | RIPA-56 has an impressive PK profile in mice, with a 3.1 h half-life, 22% oral bioavailability (PO), and 100% bioavailability from intraperitoneal injection (IP). RIPA-56 has great ability in transporting across blood brain barrier. In the SIRS mice disease model, RIPA-56 efficiently reduced tumor necrosis factor alpha (TNFα)-induced mortality and multi-organ damage[1]. |
Protocol (from reference)
Selleck's RIPA-56 has been cited by 4 publications
| TGR5 overexpression mediated by the inhibition of transcription factor SOX9 protects against hypoxia-/reoxygenation-induced injury in hippocampal neurons by activating Nrf2/HO-1 signaling [ Ann Transl Med, 2022, 10(22):1245] | PubMed: 36544646 |
| SBP-0636457, a Novel Smac Mimetic, Cooperates with Doxorubicin to Induce Necroptosis in Breast Cancer Cells during Apoptosis Blockage [ J Oncol, 2022, 2022:2390078] | PubMed: 35859663 |
| A novel chalcone derivative has antitumor activity in melanoma by inducing DNA damage through the upregulation of ROS products. [ Cancer Cell Int, 2020, 30;20:36] | PubMed: 32021565 |
| Prmt4-mediated methylation of NF-κB is critical for neural differentiation of embryonic stem cells. [ Biochem Biophys Res Commun, 2020, 10.1016/j.bbrc.2020.02.072] | PubMed: 32070496 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.