Pyrvinium pamoate

Catalog No.S5816 Batch:S581603

Technical Data

Formula

C₇₅H₇₀N₆O₆

Molecular Weight

1151.39

CAS No.

3546-41-6

Solubility (25°C)*

In vitro

DMSO

25 mg/mL (21.71 mM)

Water

Insoluble

Ethanol

Insoluble

In vivo (Add solvents to the product individually and in order)

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.400mg/ml (0.35mM)	Taking the 1 mL working solution as an example, add 50 μL of 8 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.100mg/ml (0.09mM)	Taking the 1 mL working solution as an example, add 50 μL of 2 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description	Pyrvinium pamoate(Pyrvinium embonate) is an anthelmintic effective for pinworms.

Protocol (from reference)

Selleck's Pyrvinium pamoate Has Been Cited by 18 Publications

High-throughput drug screening in advanced pre-clinical 3D melanoma models identifies potential first-line therapies for NRAS-mutated melanoma [ Journal of Experimental & Clinical Cancer Research, October 1, 2025, 278]	PubMed: nan
Synergy between Pyrvinium Pamoate and Azoles against Exophiala dermatitidis [ Antimicrobial Agents and Chemotherapy, March 27, 2018, e02361-17]	PubMed: 29437619
Pyrvinium Pamoate Induces Cell Apoptosis and Autophagy in Colorectal Cancer [ Anticancer Research, March 2024, 44(3):1193-1199]	PubMed: 38423653
Pyrvinium Pamoate Induces Cell Apoptosis and Autophagy in Colorectal Cancer [ Anticancer Research, March 15, 2024, 1193-1199]	PubMed: nan
Novel selective inhibitors of macropinocytosis-dependent growth in pancreatic ductal carcinoma [ Biomedicine & Pharmacotherapy, August 2024, 177:116991]	PubMed: 38906021
Pyrvinium Pamoate Synergizes with Azoles in vitro and in vivo to Exert Antifungal Efficacy Against Candida auris and Other Candida Species [ Infect Drug Resist, 2025, 18:783-789]	PubMed: 39958982
Wnt/β-catenin signaling is a therapeutic target in anaplastic thyroid carcinoma [ Endocrine, 2024, 10.1007/s12020-024-03887-0]	PubMed: 38806891
Repurposing FDA-Approved Drugs for Temozolomide-Resistant IDH1 Mutant Glioma Using High-Throughput Miniaturized Screening on Droplet Microarray Chip [ Adv Healthc Mater, 2023, e2300591.]	PubMed: 37162029
Synergistic effect of pyrvinium pamoate and posaconazole against Cryptococcus neoformans in vitro and in vivo [ Front Cell Infect Microbiol, 2022, 12:1074903]	PubMed: 36569209
The FDA-Approved Drug Pyrvinium Selectively Targets ER+ Breast Cancer Cells with High INPP4B Expression [ Cancers (Basel), 2022, 15(1)135]	PubMed: 36612130

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.