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Technical Data
| Formula | C23H36O7 |
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| Molecular Weight | 424.53 | CAS No. | 81093-37-0 | |
| Solubility (25°C)* | In vitro | DMSO | 85 mg/mL (200.22 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Pravastatin(CS-514) is a lipoprotein-lowering drug via reversibly inhibiting hydroxymethylglutaryl-CoA (HMG-CoA) reductase and the synthesis of very-low-density lipoproteins. |
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Protocol (from reference)
Selleck's Pravastatin has been cited by 7 publications
| Amino acid starvation-induced LDLR trafficking accelerates lipoprotein endocytosis and LDL clearance [ EMBO Rep, 2022, e53373] | PubMed: 34994492 |
| In Vitro Evidence of Statins' Protective Role against COVID-19 Hallmarks [ Biomedicines, 2022, 10(9)2123] | PubMed: 36140223 |
| In situ assessment of statins' effect on autophagic activity in zebrafish larvae cardiomyocytes [ Front Cardiovasc Med, 2022, 9:921829] | PubMed: 36465443 |
| Classic and Targeted Anti-Leukaemic Agents Interfere With the Cholesterol Biogenesis Metagene in Acute Myeloid Leukaemia: Therapeutic Implications [ J Cell Mol Med, 2020, 25] | PubMed: 32450611 |
| Pharmacological cholesterol depletion disturbs ciliogenesis and ciliary function in developing zebrafish. [ Commun Biol, 2019, 2:31] | PubMed: 30729178 |
| A dual role of cholesterol in osteogenic differentiation of bone marrow stromal cells. [ J Cell Physiol, 2019, 234(3):2058-2066] | PubMed: 30317648 |
| Statin Use at the Time of Initiation of Androgen Deprivation Therapy and Time to Progression in Patients With Hormone-Sensitive Prostate Cancer. [ JAMA Oncol, 2015, 1(4):495-504] | PubMed: 26181260 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.