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How to Cite 1. For In-Text Citation (Materials & Methods): 2. For Key Resources Table: |
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Technical Data
| Formula | C20H21N5O6.7H2O.2Na |
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| Molecular Weight | 599.50 | CAS No. | 357166-29-1 | ||||
| Solubility (25°C)* | In vitro | Water | 100 mg/mL (166.8 mM) | ||||
| DMSO | 33 mg/mL (55.04 mM) | ||||||
| Ethanol | Insoluble | ||||||
| In vivo (Add solvents to the product individually and in order) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Pemetrexed (disodium heptahydrate) is a folate antimetabolite that inhibits thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase. It also induces apoptosis and cell-cycle arrest in non-small-cell lung cancer carrying an EGFR exon 19 deletion. | ||
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Protocol (from reference)
References
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Selleck's Pemetrexed (disodium heptahydrate) Has Been Cited by 6 Publications
| Baicalin Regulates Proliferation, Apoptosis, Migration, and Invasion in Mesothelioma [ Medical Science Monitor, October 31, 2019, 8172-8180] | PubMed: 31670317 |
| Decitabine Sensitizes the Radioresistant Lung Adenocarcinoma to Pemetrexed Through Upregulation of Folate Receptor Alpha [ Frontiers in Oncology, May 17, 2021, 668798] | PubMed: 34079760 |
| A Novel Molecular Target in EGFR-mutant Lung Cancer Treated With the Combination of Osimertinib and Pemetrexed [ Anticancer Research, 2022, 709-722] | PubMed: 35093869 |
| Upregulation of Thymidylate Synthase Induces Pemetrexed Resistance in Malignant Pleural Mesothelioma [ Frontiers in Pharmacology, 2021, 718675] | PubMed: 34646134 |
| [pemetrexed + sildenafil], via autophagy-dependent HDAC downregulation, enhances the immunotherapy response of NSCLC cells [ Cancer Biology & Therapy, 2017, 705-714] | PubMed: 28812434 |
| Inhibition of Wee1 sensitizes cancer cells to anti-metabolite chemotherapeutics in vitro and in vivo, independent of p53 functionality [ Molecular Cancer Therapeutics, 2013, 2675-2684] |
RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
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