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Description
| Specificity | PARP Rabbit Recombinant mAb detects endogenous levels of PARP. |
|---|---|
| Background | Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes such as DNA repair, genomic stability, and programmed cell death. PARPs have the ability to catalyze the transfer of ADP-ribose to target proteins. There are at least 18 members of the PARP family that are encoded by different genes, and share homology in a conserved catalytic domain. A number of cellular substrates for PARP have been defined, and a majority of these proteins are nuclear proteins that are involved in nucleic acid metabolism, modulation of chromatin structure, DNA synthesis, and DNA repair. It plays a central role in NER and BER, and enables repair of DNA damage caused by alkylating agents and chemotherapeutic drugs. |
Usage Information
| Application | WB,ELISA | ||
|---|---|---|---|
| Dilution |
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| Reactivity | Human Mouse Rat | ||
| MW (kDa) | 113 kDa | ||
| Source | Rabbit | ||
| Concentration | 1mg/ml | ||
| Storage buffer | 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. | ||
| Storage (From the date of receipt) |
Store at –20°C. |
References
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Application Data
WB