ONC206

Catalog No.S6853 Batch:S685303

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Technical Data

Formula

C23H22F2N4O
Molecular Weight 408.44 CAS No. 1638178-87-6
Solubility (25°C)* In vitro DMSO 82 mg/mL (200.76 mM)
Ethanol 20 mg/mL (48.96 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
4.1mg/ml Taking the 1 mL working solution as an example, add 50 μL of 82 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
Clear solution
5% DMSO 95% Corn oil
1.0mg/ml Taking the 1 mL working solution as an example, add 50 μL of 20 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description ONC206 is a selective antagonist of DRD2/3/4 with broad-spectrum anti-tumor activity.
Targets
DRD2 [1]
In vitro

ONC206 is a ClpP agonist regarding the requirement of high doses (50–130 mg/kg) to achieve in vivo efficacy. [2]

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    SUM159 and MDA‐MB‐231 (WT and CLPP‐KO) cell lines

  • Concentrations

    --

  • Incubation Time

    72 h

  • Method

    Cells were treated with indicated drug concentrations for 72 h and imaged following addition of Hoechst stain.

    (Data sourced from selleck products)

Selleck's ONC206 has been cited by 2 publications

Dopamine receptor D2 regulates glioblastoma survival and death through MET and death receptor 4/5 [ Neoplasia, 2023, 39:100894] PubMed: 36972629
Characterization of TR-107, a novel chemical activator of the human mitochondrial protease ClpP [ Pharmacol Res Perspect, 2022, 10(4):e00993] PubMed: 35929764

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.