NSC95397

Catalog No.S6777 Batch:S677701

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Technical Data

Formula

C14H14O4S2

Molecular Weight 310.39 CAS No. 93718-83-3
Solubility (25°C)* In vitro DMSO 62 mg/mL (199.74 mM)
Ethanol 2 mg/mL (6.44 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description NSC 95397 is a potent, selective Cdc25 dual specificity phosphatase inhibitor with Ki of 32 nM, 96 nM, 40 nM for Cdc25A, Cdc25B and Cdc25C, respectively. NSC 95397 has IC50 of 22.3 nM, 56.9 nM and 125 nM for human Cdc25A, human Cdc25C and Cdc25B, respectively. NSC 95397 inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) and suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and ERK1/2 pathway.
Targets
MKP-1 [2] Cdc25A [1]
(Cell-free assay)
Cdc25A [1]
(Cell-free assay)
Cdc25C [1]
(Cell-free assay)
Cdc25B [1]
(Cell-free assay)
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22.3 nM 32 nM(Ki) 40 nM(Ki) 56.9 nM

Protocol (from reference)

Selleck's NSC95397 has been cited by 1 publication

Tetrahydrocurcumin improves lipopolysaccharide-induced myocardial dysfunction by inhibiting oxidative stress and inflammation via JNK/ERK signaling pathway regulation [ Phytomedicine, 2022, 104:154283] PubMed: 35779282

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.