NS8593 Hydrochloride

Catalog No.S6174 Batch:S617401

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Technical Data

Formula

C17H18ClN3

Molecular Weight 299.8 CAS No. 875755-24-1
Solubility (25°C)* In vitro DMSO 60 mg/mL (200.13 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description NS8593 is a potent negative gating inhibitor of small conductance Ca2+ -activated K+ channels (SK1-3 or Kca2.1-2.3 channels). NS8593 is also a potent inhibitor of the TRPM7 channel with an IC50 of 1.6 µM.
Targets
Ca2+-activated K+ channels [2] TRPM7 channel [1]
1.6 µM

Protocol (from reference)

Selleck's NS8593 Hydrochloride has been cited by 1 publication

Shape memory and hemostatic silk-laponite scaffold for alveolar bone regeneration after tooth extraction trauma [ Int J Biol Macromol, 2024, 260(Pt 2):129454] PubMed: 38237836

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.