(−)-Norepinephrine

Catalog No.S9507 Batch:S950703

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Technical Data

Formula

C8H11NO3
Molecular Weight 169.18 CAS No. 51-41-2
Solubility (25°C)* In vitro DMSO 3 mg/mL (17.73 mM)
Water Insoluble
Ethanol Insoluble
In vivo (Add solvents to the product individually and in order)
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description (−)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.This compound can be used to induce animal models of Cardiomyopathy.
Targets
α2A adrenoceptor [1]
(CHO-C10 cells)		 α1 adrenoceptor [1]
(cell-based assay)		 β1 adrenoceptor [1]
(cell-based assay)
56 nM(Ki) 330 nM(Ki) 740 nM(Ki)
In vitro

(-)-Norepinephrine inhibits the production of TNF-α, IL-6, and CXCL2/MIP-2 and promotes the secretion of IL-10 from LPS-stimulated murine alveolar macrophages. This compound down-regulates NF-κB activation in stimulated alveolar macrophages.

In vivo

Injection of (-)-Norepinephrine into senescence-accelerated prone 8 (SAMP8) mice reverses formaldehyde accumulation and this compound deficiency and restored the magnitude of long-term potentiation and memory.

Protocol (from reference)

References

  • https://pubmed.ncbi.nlm.nih.gov/17303246/
  • https://pubmed.ncbi.nlm.nih.gov/32643759/
  • https://pubmed.ncbi.nlm.nih.gov/25866202/

Selleck's (−)-Norepinephrine Has Been Cited by 19 Publications

The therapeutic effects of labetalol in chronic stress and immuno-agonists-induced cough hypersensitivity and lung inflammation involve reducing IFN-γ-producing T lymphocytes [ ERJ Open Research, September 4, 2025, 00342-2025] PubMed: nan
The therapeutic effects of labetalol in chronic stress and immuno-agonists-induced cough hypersensitivity and lung inflammation involve reducing IFN-γ-producing T lymphocytes [ ERJ Open Research, September 04, 2025, 00342-2025]
Paraventricular nucleus CRH neurons regulate acute lung injury via sympathetic nerve-neutrophil axis [ Nature Communications, October 6, 2025, 8870] PubMed: 41053178
Mechanistic Exploration of Shugan Jianpi Formula for Treating Triple-Negative Breast Cancer Under Chronic Stress: A Network Pharmacology-Guided Experimental Study [ Drug Design, Development and Therapy, May 31, 2025, 4585-4603] PubMed: 40469627
Sympathetic Neurons Promote Small Cell Lung Cancer through the β2-Adrenergic Receptor [ Cancer Discovery, March 3, 2025, 616-632] PubMed: 39513738
Tumor-Associated Sympathetic Nerves Promote the Progression of Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma [ Advanced Science, June 9, 2025, e13580] PubMed: 40488319
Suppression of trabecular meshwork phagocytosis by norepinephrine is associated with nocturnal increase in intraocular pressure in mice [ Communications Biology, April 8, 2022, 339] PubMed: 35396348
Mechanistic Exploration of Shugan Jianpi Formula for Treating Triple-Negative Breast Cancer Under Chronic Stress: A Network Pharmacology-Guided Experimental Study [ Drug Design, Development and Therapy, 2025, 4585-4603] PubMed: 40469627
Mechanistic Exploration of Shugan Jianpi Formula for Treating Triple-Negative Breast Cancer Under Chronic Stress: A Network Pharmacology-Guided Experimental Study [ Drug Des Devel Ther, 2025, 19:4585-4603] PubMed: 40469627
Norepinephrine ameliorates sepsis-associated acute kidney injury through inhibiting damage of renal tubular epithelium induced by macrophage inflammatory response [ BMC Nephrology, 2025, 498] PubMed: 40883684

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.