NIK SMI1

Catalog No.S8941 Batch:S894101

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Technical Data

Formula

C20H19N3O4

 

Molecular Weight 365.38 CAS No. 1660114-31-7
Solubility (25°C)* In vitro DMSO 73 mg/mL (199.79 mM)
Water Insoluble
Ethanol Insoluble
In vivo (Add solvents to the product individually and in order)
5% DMSO 95% Corn oil
0.9mg/ml
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
3.65mg/ml
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description NIK SMI1 is a highly potent and selective NF-κB-inducing kinase (NIK) inhibitor with Ki of 0.23 nM for NIK-catalyzed hydrolysis of ATP to ADP.
Targets
NIK-catalyzed hydrolysis of ATP to ADP [1]
0.23 nM(Ki)
In vitro

NIK SMI1 exhibits selective inhibition of LTβR-dependent p52 translocation and transcription of NF-κB2 related genes. NIK SMI1 is shown to have a favorable pharmacokinetic profile across species and to inhibit BAFF-induced B cell survival in vitro.[1]

In vivo

NIK SMI1 inhibits BAFF signaling and reduces splenic marginal zone B cells in vivo.[1]

Protocol (from reference)

Animal Study:

[1]

  • Animal Models

    C57BL/6 mice

  • Dosages

    10 mg/kg, 20 mg/kg, 60 mg/kg, 100 mg/kg, 200 mg/kg

  • Administration

    Oral gavage

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.