NB 598

Catalog No.S0338 Batch:S033802

Print

Technical Data

Formula

C27H31NOS2

Molecular Weight 449.67 CAS No. 131060-14-5
Solubility (25°C)* In vitro DMSO 90 mg/mL (200.14 mM)
Ethanol 6 mg/mL (13.34 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
4.5mg/ml
5% DMSO 95% Corn oil
2.25mg/ml
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description NB-598 is a potent, competitive squalene epoxidase (SE) inhibitor. NB-598 suppresses cholesterol biosynthesis.
Targets
squalene epoxidase [1] cholesterol [1]
In vitro

NB598 is squalene epoxidase inhibitor that significantly inhibits endogenous cholesterol biosynthesis, resulting in impaired β-cell insulin secretion.

Protocol (from reference)

Cell Assay:

[2]

  • Cell lines

    MIN6 cells

  • Concentrations

    10 μM

  • Incubation Time

    48 h

  • Method

    Cells were treated with indicated concentration of drug for 48 h.

Animal Study:

[3]

  • Animal Models

    Female CD rats

  • Dosages

    5.1 mg/kg

  • Administration

    p.o.

Selleck's NB 598 has been cited by 3 publications

SQLE promotes pancreatic cancer growth by attenuating ER stress and activating lipid rafts-regulated Src/PI3K/Akt signaling pathway [ Cell Death Dis, 2023, 14(8):497] PubMed: 37542052
SQLE promotes pancreatic cancer growth by attenuating ER stress and activating lipid rafts-regulated Src/PI3K/Akt signaling pathway [ Cell Death Dis, 2023, 14(8):497] PubMed: 37542052
MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer [ Nat Commun, 2021, 12(1):5066] PubMed: 34417456

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.