MSX-122

Catalog No.S6617 Batch:S661701

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Technical Data

Formula

C16H16N6
Molecular Weight 292.34 CAS No. 897657-95-3
Solubility (25°C)* In vitro DMSO 3 mg/mL (10.26 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description MSX-122 (Q-122) is a novel small molecule and partial CXCR4 antagonist (IC50~10 nM).
Targets
CXCR4 [1]
~10 nM
In vitro

MSX-122 is also incapable of blocking the binding of 125I-labeled CXCL12 to CXCR4. MSX-122 appears to be insufficiently large to block all binding sites between CXCR4 and CXCL12. MSX-122 blocks certain CXCR4 functions via binding to the CXCL12-binding site and interfering with CXCR4/CXCL12-mediated signaling. MSX-122 can intervene in the Gαi-signaling pathway (cAMP modulation), but not the Gq-pathway (calcium flux)[1].
In vivo

MSX-122 blocks bleomycin-induced lung fibrosis involving chemotaxis and homing of CXCR4-positive mesenchymal progenitor cells into the lungs. MSX-122 exhibits anti-inflammatory activity in a carrageenan-induced paw edema model. MSX-122 blocks lung metastasis of breast cancer and SCCHN, and liver metastasis of uveal melanoma in vivo[1].

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    MDA-MB-231 cells

  • Concentrations

    1, 10, 100, and 1000 nM

  • Incubation Time

    15 mins

  • Method

    For binding affinity assay, MDA-MB-231 cells cultured in an 8-well slide chamber are preincubated with MSX-122 at 1, 10, 100, and 1000 nM. Then the cells are fixed with 4% formaldehyde and incubated with 50 nM biotinylated TN14003, and followed by Rhodamine staining.
Animal Study:

[1]
  • Animal Models

    Male C57BL/6 mice (age 5–6 weeks)

  • Dosages

    10 mg/kg

  • Administration

    i.p. injection

Selleck's MSX-122 has been cited by 1 publication

Microbial-Dependent Recruitment of Immature Myeloid Cells Promotes Intestinal Regeneration [ Cell Mol Gastroenterol Hepatol, 2023, 10.1016/j.jcmgh.2023.10.007] PubMed: 37898454

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.